Tuberculosis among children visiting friends & relatives

被引：6

作者：

Perez-Porcuna, Tomas M. ^{[1
,2
,30
]}

Noguera-Julian, Antoni ^{[3
]}

Riera-Bosch, Maria Teresa ^{[4
]}

Macia-Rieradevall, Esperanca ^{[5
]}

Santos-Santiago, Jose ^{[6
]}

Pujol, Maria Angels Rifa ^{[7
]}

Eril, Maria ^{[8
]}

Aulet-Molist, Lidia ^{[9
]}

Padilla-Esteba, Emma ^{[10
]}

Tortola, Maria Teresa ^{[11
]}

Prat, Jordi ^{[12
]}

Bastarras, Anna Vilamala ^{[13
]}

Rebull-Fatsini, Josep Sebastia ^{[14
]}

Papaleo, Andrea ^{[15
]}

Rius-Gordillo, Neus ^{[16
]}

Goncalves, Alessandra Q. ^{[17
]}

Naranjo-Orihuela, Angels ^{[18
]}

Urgelles, Marta ^{[19
]}

Garcia-Lerin, Monica G. ^{[20
]}

Jimenez-Lladser, Gemma ^{[21
]}

Lorenzo-Pino, Beatriz ^{[22
]}

Giuliano-Cuello, Monica Adriana ^{[23
]}

Pascual-Sanchez, Maria Teresa ^{[16
]}

Marco-Garcia, Monica ^{[24
]}

Abellana, Rosa ^{[25
]}

Espiau, Maria ^{[26
]}

Altet-Gomez, Maria Nieves ^{[27
]}

Orcau-Palau, Angels ^{[28
]}

Cayla, Joan A. ^{[29
]}

Soriano-Arandes, Antoni

机构：

[1] Res Fdn Primary Hlth, TB Pediat Unit, Terrassa 08221, Catalunya, Spain

[2] Mutua Terassa Univ Hosp, Terrassa 08221, Catalunya, Spain

[3] Inst Recerca St Joan de Deu, Malalties Infeccioses & Resposta Inflamatoria Sist, Serv Infectol Pediat, Barcelona 08950, Spain

[4] Inst Catala Salut, EAP Vic Nord SAP Osona, Barcelona 08007, Spain

[5] EAP Manlleu, Inst Catala Salut Catalunya Cent, Barcelona 08007, Spain

[6] Inst Catala Salut, Salut Int & Malalties Transmisibles Drassanes i, Barcelona 08001, Spain

[7] Inst Catala Salut, EAP Tona, Barcelona 08007, Spain

[8] Inst Catala Salut, EAP Vall del Ges, Barcelona 08007, Spain

[9] EAP Vic Sud, CAP Remei Vic, Barcelona 08500, Spain

[10] CATLAB, Microbiol Dept, Viladecavalls 08232, Catalunya, Spain

[11] Hosp Univ Vall dHebron, Microbiol Dept, Barcelona 08035, Barcelona, Spain

[12] PROSICS, Unit Trop Med & Int Hlth Drassanes Vall dHebron UT, Publ Hlth & Community Team eSPiC, Barcelona 08028, Spain

[13] Hosp Univ Vic, Multidisciplinary Inflammat Res Grp MIRG, Barcelona 08500, Spain

[14] Hosp Tortosa Verge de la Cinta, Serv Med Prevent, Tortosa, Spain

[15] Inst Catala Salut, CAP Magoria, Barcelona 08014, Spain

[16] Hosp Univ Sant Joan de Reus, Serv Pediat, Reus 43204, Spain

[17] Fundacio Inst Univ Recerca Atencio Primaria Salut, Unitat Suport Recerca Terres Ebre, Tortosa 43500, Spain

[18] Inst Catala Salut, ABS Montblanc, Barcelona 08007, Spain

[19] Fundacio Assistencial Mutua Terrassa, CAP Terrassa Sud, Terrassa 08221, Spain

[20] Fundacio Assistencial Mutua Terrassa, CAP Rambla Terrassa, Terrassa 08221, Spain

[21] Fundacio Assistencial Mutua Terrassa, CAP Valldoreix, Terrassa 08221, Spain

[22] Fundacio Assistencial Mutua Terrassa, CAP Rubi Mutua Terrassa, Terrassa 08221, Spain

[23] Fdn Asistencial Mutua Terrassa, CAP Oest, Terrassa 08221, Spain

[24] Inst Catala Salut, EAP Maragall, Barcelona 08007, Spain

[25] Univ Barcelona, Unitat Bioestat, Barcelona 08007, Spain

[26] Childrens Hosp Vall dHebron Barcelona Hosp Campus, Paediat Infect Dis & Immunodeficiencies Unit, Barcelona 08035, Spain

[27] Serv Clin, Barcelona 08036, Catalonia, Spain

[28] Agencia Salut Publ Barcelona, Barcelona 08023, Spain

[29] Fdn TB Res Unit Barcelona fuiTB, Barcelona, Spain

[30] Res Fundat Mutua Terrassa, C St Antoni 19, Terrassa 08221, Spain

来源：

JOURNAL OF TRAVEL MEDICINE | 2024年 / 31卷 / 06期

关键词：

Tuberculosis; latent TB infection; visiting friends and relatives; children; epidemiology; MYCOBACTERIUM-TUBERCULOSIS; SKIN-TESTS; INFECTION; RISK; PREVALENCE;

D O I：

10.1093/jtm/taae037

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Most paediatric tuberculosis (TB) cases in low-TB-incidence countries involve children born to migrant families. This may be partially explained by trips to their countries of origin for visiting friends and relatives (VFR). We aimed to estimate the risk of latent TB infection (LTBI) and TB in children VFR. Methods We conducted a prospective multicentric observational study in Catalonia (Spain) from June 2017 to December 2019. We enrolled children aged < 15 years with a negative tuberculin skin test (TST) at baseline and at least one parent from a high-TB-incidence country, and who had travelled to their parent's birth country for >= 21 days. TST and QuantiFERON-TB Gold Plus (QFT-Plus) were performed within 8-12 weeks post-return. LTBI was defined as a TST >= 5 mm and/or a positive QFT-Plus. Results Five hundred children completed the study, equivalent to 78.2 person-years of follow-up (PYFU). Thirteen children (2.6%) were diagnosed with LTBI (16.6/per100 PYFU, 95%CI = 8.8-28.5), including two cases (0.4%) of TB (2.5/per100 PYFU, 95%CI = 0.3-9.3). LTBI incidence rates remained high after excluding BCG-vaccinated children (9.7/per100 PYFU, 95%CI = 3.9-20.0). Household tobacco smoke exposure was associated with LTBI (aOR = 3.9, 95%CI = 1.1-13.3). Conclusions The risk of LTBI in children VFR in high-TB-incidence countries may equal, or perhaps even exceed, the infection risk of the native population. The primary associated risk factor was the presence of smokers in the household. Furthermore, the incidence rate of active TB largely surpassed that of the countries visited. Children VFR in high-TB-incidence countries should be targeted for diagnostic and preventive interventions.

引用

页数：8

共 35 条

[1] Latent tuberculosis infection in foreign-born communities: Import vs. transmission in The Netherlands derived through mathematical modelling [J].

Altes, Hester Korthals ;

Kloet, Serieke ;

Cobelens, Frank ;

Bootsma, Martin .

PLOS ONE, 2018, 13 (02)

[2] Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children [J].

Altet, Neus ;

Latorre, Irene ;

Jimenez-Fuentes, Maria Angeles ;

Soriano-Arandes, Antoni ;

Villar-Hernandez, Raquel ;

Mila, Celia ;

Rodriguez-Fernandez, Pablo ;

Muriel-Moreno, Beatriz ;

Comella-del-Barrio, Patricia ;

Godoy, Pere ;

Millet, Joan-Pau ;

de Souza-Galvao, Maria Luiza ;

Jimenez-Ruiz, Carlos A. ;

Dominguez, Jose .

JOURNAL OF CLINICAL MEDICINE, 2022, 11 (07)

[3]

American Academy of Pediatrics Committee on Infectious Diseases, 2021, Red Book: 20212024 Report of the Committee on Infectious Diseases / Committee on Infectious Diseases, American Academy of Pediatrics, V32nd

[4]

[Anonymous], 2021, Tuberculosis surveillance and monitoring in Europe 2021 (2019 data)

[5]

[Anonymous], LAT TUB INF UPD CONS

[6]

Baquero-Artigao F, 2023, AN PEDIATR, V98, P460, DOI [10.1016/j.anpedi.2023.03.011, 10.1016/j.anpede.2023.03.009]

[7] Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections [J].

Bhat, Tariq A. ;

Kalathil, Suresh Gopi ;

Bogner, Paul N. ;

Miller, Austin ;

Lehmann, Paul V. ;

Thatcher, Thomas H. ;

Phipps, Richard P. ;

Sime, Patricia J. ;

Thanavala, Yasmin .

JOURNAL OF IMMUNOLOGY, 2018, 200 (08) :2927-2940

[8]

Brophy J, 2015, Can Commun Dis Rep, V41, P89

[9] A Primary Care-Based Quality Improvement Initiative to Increase Identification of Pediatric International Travelers [J].

Campbell, Jeffrey I. ;

Alonso, Andrea ;

Cuttin, Karen ;

Sanchez, Miralia ;

Schumacher, Sandra ;

Ozonoff, Al ;

Epee-Bounya, Alexandra ;

Sharma, Tanvi ;

Antkowiak, Lara .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2020, 102 (05) :1016-1021

[10] Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity [J].

Cobelens, FGJ ;

van Deutekom, H ;

Draayer-Jansen, IWE ;

Schepp-Beelen, ACHM ;

van Gerven, PJHJ ;

van Kessel, RPM ;

Mensen, MEA .

LANCET, 2000, 356 (9228) :461-465

← 1 2 3 4 →