177Lu-DOTATATE (Lutathera) Therapy in 68Ga-DOTATATE PET/CT-Negative Liver Metastases of a Neuroendocrine Tumor

被引：2
作者：
Ventura, David [1 ]
Roll, Wolfgang [1 ]
Kasper, Hans-Udo [2 ]
Rahbar, Kambiz [1 ]
Stegger, Lars [1 ]
机构：
[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany
[2] Clemenshosp Muenster, Inst Pathol, Munster, Germany
来源：
CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 12期
关键词：
PRRT; GEP-NET; PET/CT; DOTATATE; SSTR; ANALOG;
D O I：
10.1097/RLU.0000000000004888
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 73-year-old man with metastatic pancreatic neuroendocrine tumor was evaluated with Ga-68-DOTATATE PET/CT for peptide receptor radionuclide therapy. Both PET-positive and negative lesions were seen in the liver, along with extrahepatic metastases. Histopathology was obtained from one of the PET-negative liver lesions to exclude secondary malignancy. Histology confirmed a well-differentiated (G2) metastasis of pNET with high somatostatin receptor expression. We initiated peptide receptor radionuclide therapy with close monitoring of the PET-negative liver metastases. We present a rare case, where posttherapeutic scintigraphy revealed vigorous uptake of Lu-177-DOTATATE even in the Ga-68-DOTATATE PET-negative liver metastases. Follow-up PET/CT showed a partial response to therapy.
引用
收藏
页码：E585 / E587
页数：3
相关论文
共 50 条
[41]   177Lu-DOTATATE PRRT for Multiple Unusual Metastatic Sites in Neuroendocrine Tumor [J].
Parghane, Rahul, V ;
Basu, Sandip .
CLINICAL NUCLEAR MEDICINE, 2022, 47 (10) :874-875
[42]   Paraganglioma and Pancreatic Neuroendocrine Tumor With Rare Metastatic Sites Detected on 68Ga-DOTATATE PET/CT Imaging [J].
Parghane, Rahul Vithalrao ;
Mittal, Bhagwant Rai ;
Shukla, Jaya ;
Dey, Pranab ;
Bhattacharya, Anish ;
Kochhar, Rakesh .
CLINICAL NUCLEAR MEDICINE, 2015, 40 (03) :256-257
[43]   68Ga-DOTATATE PET/CT in the evaluation of patients with neuroendocrine metastatic carcinoma of unknown origin [J].
Alonso, Omar ;
Rodriguez-Taroco, Monica ;
Savio, Eduardo ;
Bentancourt, Cecilia ;
Gambini, Juan P. ;
Engler, Henry .
ANNALS OF NUCLEAR MEDICINE, 2014, 28 (07) :638-645
[44]   68Ga-DOTATATE PET/CT in the evaluation of patients with neuroendocrine metastatic carcinoma of unknown origin [J].
Omar Alonso ;
Mónica Rodríguez-Taroco ;
Eduardo Savio ;
Cecilia Bentancourt ;
Juan P. Gambini ;
Henry Engler .
Annals of Nuclear Medicine, 2014, 28 :638-645
[45]   Pancreatic Perivascular Epithelioid Cell Tumor Revealed by 68Ga-DOTATATE PET/CT [J].
Sun, Rui ;
Zeng, Guangping ;
Chen, XiaoLiang .
CLINICAL NUCLEAR MEDICINE, 2023, 48 (06) :515-517
[46]   Radiomics-Based Texture Analysis of 68Ga-DOTATATE Positron Emission Tomography and Computed Tomography Images as a Prognostic Biomarker in Adults With Neuroendocrine Cancers Treated With 177Lu-DOTATATE [J].
Atkinson, Charlotte ;
Ganeshan, Balaji ;
Endozo, Raymond ;
Wan, Simon ;
Aldridge, Matthew D. ;
Groves, Ashley M. ;
Bomanji, Jamshed B. ;
Gaze, Mark N. .
FRONTIERS IN ONCOLOGY, 2021, 11
[47]   68Ga-DOTATATE PET/CT findings in primary malignant lung glomic tumor [J].
Yin, H. ;
Shi, H. .
MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE, 2025, 49 (03) :213-214
[48]   A Rare Case of Pituitary Carcinoma With Bone Metastases: 68Ga-DOTATATE PET/CT Findings [J].
Filizoglu, Nuh ;
Ozguven, Salih .
CLINICAL NUCLEAR MEDICINE, 2022, 47 (03) :E298-E299
[49]   Incidental Uptake in Benign Gynecomastia on 68Ga-DOTATATE PET/CT [J].
Pandika, Veska ;
Covington, Matthew F. .
CLINICAL NUCLEAR MEDICINE, 2019, 44 (10) :799-800
[50]   Synchronous Endometrial Cancer Detected on 68Ga-DOTATATE PET/CT [J].
Mohammadinejad, Payam ;
Kim, Alex ;
Koshevarova, Victoria ;
Murphy, Micah ;
Shagun, F. N. U. ;
Bhargava, Peeyush .
CLINICAL NUCLEAR MEDICINE, 2024, 49 (01) :96-97
12345