177Lu-DOTATATE (Lutathera) Therapy in 68Ga-DOTATATE PET/CT-Negative Liver Metastases of a Neuroendocrine Tumor

被引：2
作者：
Ventura, David [1 ]
Roll, Wolfgang [1 ]
Kasper, Hans-Udo [2 ]
Rahbar, Kambiz [1 ]
Stegger, Lars [1 ]
机构：
[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany
[2] Clemenshosp Muenster, Inst Pathol, Munster, Germany
来源：
CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 12期
关键词：
PRRT; GEP-NET; PET/CT; DOTATATE; SSTR; ANALOG;
D O I：
10.1097/RLU.0000000000004888
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 73-year-old man with metastatic pancreatic neuroendocrine tumor was evaluated with Ga-68-DOTATATE PET/CT for peptide receptor radionuclide therapy. Both PET-positive and negative lesions were seen in the liver, along with extrahepatic metastases. Histopathology was obtained from one of the PET-negative liver lesions to exclude secondary malignancy. Histology confirmed a well-differentiated (G2) metastasis of pNET with high somatostatin receptor expression. We initiated peptide receptor radionuclide therapy with close monitoring of the PET-negative liver metastases. We present a rare case, where posttherapeutic scintigraphy revealed vigorous uptake of Lu-177-DOTATATE even in the Ga-68-DOTATATE PET-negative liver metastases. Follow-up PET/CT showed a partial response to therapy.
引用
收藏
页码：E585 / E587
页数：3
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