177Lu-DOTATATE (Lutathera) Therapy in 68Ga-DOTATATE PET/CT-Negative Liver Metastases of a Neuroendocrine Tumor

被引：2

作者：

Ventura, David ^{[1
]}

Roll, Wolfgang ^{[1
]}

Kasper, Hans-Udo ^{[2
]}

Rahbar, Kambiz ^{[1
]}

Stegger, Lars ^{[1
]}

机构：

[1] Univ Hosp Muenster, Dept Nucl Med, Albert Schweitzer Campus 1,Gebaude A1, D-48149 Munster, Germany

[2] Clemenshosp Muenster, Inst Pathol, Munster, Germany

来源：

CLINICAL NUCLEAR MEDICINE | 2023年 / 48卷 / 12期

关键词：

PRRT; GEP-NET; PET/CT; DOTATATE; SSTR; ANALOG;

D O I：

10.1097/RLU.0000000000004888

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 73-year-old man with metastatic pancreatic neuroendocrine tumor was evaluated with Ga-68-DOTATATE PET/CT for peptide receptor radionuclide therapy. Both PET-positive and negative lesions were seen in the liver, along with extrahepatic metastases. Histopathology was obtained from one of the PET-negative liver lesions to exclude secondary malignancy. Histology confirmed a well-differentiated (G2) metastasis of pNET with high somatostatin receptor expression. We initiated peptide receptor radionuclide therapy with close monitoring of the PET-negative liver metastases. We present a rare case, where posttherapeutic scintigraphy revealed vigorous uptake of Lu-177-DOTATATE even in the Ga-68-DOTATATE PET-negative liver metastases. Follow-up PET/CT showed a partial response to therapy.

引用

页码：E585 / E587

页数：3

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