Type I interferon and cancer

被引:34
作者
Holicek, Peter [1 ,2 ,3 ]
Guilbaud, Emma [4 ]
Klapp, Vanessa [5 ,6 ]
Truxova, Iva [1 ]
Spisek, Radek [1 ,2 ,3 ]
Galluzzi, Lorenzo [4 ,7 ,8 ,9 ]
Fucikova, Jitka [1 ,2 ,3 ]
机构
[1] Sotio Biotech, Prague, Czech Republic
[2] Charles Univ Prague, Fac Med 2, Dept Immunol, Prague, Czech Republic
[3] Univ Hosp Motol, Prague, Czech Republic
[4] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY USA
[5] Luxembourg Inst Hlth, Dept Canc Res, Tumor Stroma Interact, Strassen, Luxembourg
[6] Univ Luxembourg, Fac Sci Technol & Med, Esch Sur Alzette, Luxembourg
[7] Sandra & Edward Meyer Canc Ctr, New York, NY USA
[8] Caryl & Israel Englander Inst Precis Med, New York, NY USA
[9] Weill Cornell Med Coll, New York, NY 10065 USA
关键词
apoptotic cell death; CGAS; interferon-stimulated genes; immunogenic cell death; pattern recognition receptors; STING1; DOUBLE-STRANDED-RNA; PLASMACYTOID DENDRITIC CELLS; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELL; REGULATORY T-CELL; IFN-ALPHA; CYCLIC DINUCLEOTIDE; MEDIATED APOPTOSIS; UP-REGULATION; HUMAN-BREAST;
D O I
10.1111/imr.13272
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at least some) malignant cells, but also their pronounced immunostimulatory functions. In line with this notion, type I IFN signaling has been implicated in the antineoplastic effects of various immunogenic therapeutics, including (but not limited to) immunogenic cell death (ICD)-inducing agents and immune checkpoint inhibitors (ICIs). On the other hand, weak, indolent, and non-resolving type I IFN responses have been demonstrated to support tumor progression and resistance to therapy, reflecting the ability of suboptimal type I IFN signaling to mediate cytoprotective activity, promote stemness, favor tolerance to chromosomal instability, and facilitate the establishment of an immunologically exhausted tumor microenvironment. Here, we review fundamental aspects of type I IFN signaling and their context-dependent impact on malignant transformation, tumor progression, and response to therapy.
引用
收藏
页码:115 / 127
页数:13
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