CircRNAs: A Novel Strategy in Diagnosis and Treatment of Thyroid Cancer

被引：2
作者：
Shafabakhsh, Rana [1 ]
Asemi, Zatollah [1 ]
Mansournia, Mohammad Ali [2 ]
Yousefi, Bahman [3 ,4 ]
Hallajzadeh, Jamal [5 ,6 ]
机构：
[1] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran
[3] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran
[4] Tabriz Univ Med Sci, Fac Med, Dept Biochem, Tabriz, Iran
[5] Maragheh Univ Med Sci, Res Ctr Evidence Based Hlth Management, Dept Biochem & Nutr, Maragheh, Iran
[6] Maragheh Univ Med Sci, Res Ctr Evidence Based Hlth Management, Maragheh, Iran
来源：
CURRENT MOLECULAR MEDICINE | 2023年 / 23卷 / 08期
关键词：
CircRNAs; apoptosis; microRNA; signaling pathway; thyroid cancer; neuroendocrine cell; BRAF V600E MUTATION; CIRCULAR RNAS; GENE-EXPRESSION; DOWN-REGULATION; EMERGING ROLES; CELL APOPTOSIS; WIDE ANALYSIS; BETA-CATENIN; KAPPA-B; CARCINOMA;
D O I：
10.2174/1566524022666220701141914
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Thyroid cancer is one of the most frequent cancers globally, and its incidence has risen recently. The clinical behavior of thyroid cancer includes a wide range, from benign to invasive malignant tumors. Thus, precious diagnostic activities before therapeutic work are required. Circular RNAs (circRNAs) along with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are known as non-coding RNAs (ncRNAs). Large amounts of investigations have indicated that circRNAs can participate in multiple cellular processes, especially in tumorigenesis. Furthermore, circRNAs are stable in blood or plasma, as well as they are specific in different tissues. Therefore, they could serve as a potential diagnostic biomarker for cancer cells. Limited studies investigated the role of circRNAs in some processes involved in thyroid cancer. In this review, we summarized the current evidence on the potential clinical involvement of circRNAs in thyroid cancer.
引用
收藏
页码：737 / 747
页数：11
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