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Recent Advances in Cancer Immunotherapy Delivery Modalities
被引:12
|作者:
Muthukutty, Palaniyandi
[1
]
Woo, Hyun Young
[2
,3
]
Ragothaman, Murali
[1
]
Yoo, So Young
[1
]
机构:
[1] Pusan Natl Univ, BIOIT Foundry Technol Inst, Busan 46241, South Korea
[2] Pusan Natl Univ Hosp, Dept Internal Med, Busan 49241, South Korea
[3] Pusan Natl Univ Hosp, Med Res Inst, Busan 49241, South Korea
关键词:
drug delivery;
cancer immunotherapy;
CAR-T cells;
nanoparticles;
INJECTABLE POLYPEPTIDE HYDROGEL;
COLONY-STIMULATING FACTOR;
ONCOLYTIC VACCINIA VIRUS;
MODIFIED T-CELLS;
DRUG-DELIVERY;
CO-DELIVERY;
ANTITUMOR IMMUNITY;
TUMOR-GROWTH;
PHASE-II;
IN-VIVO;
D O I:
10.3390/pharmaceutics15020504
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Immunotherapy is crucial in fighting cancer and achieving successful remission. Many novel strategies have recently developed, but there are still some obstacles to overcome before we can effectively attack the cancer cells and decimate the cancer environment by inducing a cascade of immune responses. To successfully demonstrate antitumor activity, immune cells must be delivered to cancer cells and exposed to the immune system. Such cutting-edge technology necessitates meticulously designed delivery methods with no loss or superior homing onto cancer environments, as well as high therapeutic efficacy and fewer adverse events. In this paper, we discuss recent advances in cancer immunotherapy delivery techniques, as well as their future prospects.
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页数:24
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