Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study

被引：8

作者：

Boczar, Kevin E. E. ^{[1
,2
,3
,4
]}

Beanlands, Rob S. S.

Glassman, Steven J. J.

Wang, Jerry

Zeng, Wanzhen ^{[1
,3
]}

deKemp, Robert A. A. ^{[1
]}

Ward, Natalie C. C.

Fehlmann, Christophe A. A. ^{[2
,6
,7
]}

Wells, George A. A. ^{[1
,8
]}

Karsh, Jacob

Dwivedi, Girish ^{[1
,3
,5
,9
,10
,11
]}

机构：

[1] Univ Ottawa Heart Inst, Ottawa, ON, Canada

[2] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[3] Univ Ottawa, Ottawa, ON, Canada

[4] Univ Penn, Perelman Sch Med, Dept Med, Div Cardiol, Philadelphia, PA USA

[5] Univ Western Australia, Sch Med, Perth, WA, Australia

[6] Ottawa Hosp Res Inst, Ottawa, ON, Canada

[7] Geneva Univ Hosp, Div Emergency Med, Geneva, Switzerland

[8] Univ Ottawa Heart Inst, Res Methods Ctr, Ottawa, ON, Canada

[9] Harry Perkins Inst Med Res, Dept Adv Clin & Translat Cardiovasc Imaging, Murdoch, Australia

[10] Fiona Stanley Hosp, Dept Cardiol, Murdoch, WA, Australia

[11] Curtin Univ, Sch Biomed Sci, Bentley, WA, Australia

来源：

JOURNAL OF NUCLEAR CARDIOLOGY | 2023年 / 30卷 / 04期

基金：

加拿大健康研究院;

关键词：

Psoriatic arthritis; inflammation; PET imaging; cardiovascular disease; ATHEROSCLEROTIC PLAQUE INFLAMMATION; AORTIC VASCULAR INFLAMMATION; RISK; SEVERITY; ARTERY; MORTALITY; ARTHRITIS; SKIN;

D O I：

10.1007/s12350-023-03204-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AimThe aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by Rb-82 PET following therapy with biologic agents for 6 months in patients with psoriatic arthritis (PsA) and/or cutaneous psoriasis (PsO) (group 1) and compare with PsO subjects receiving non-biologic therapy (group 2) and controls (group 3).Methods and ResultsTarget-to-background ratio (TBR) by FDG PET in the most diseased segment of the ascending aorta (TBRmax) was measured to assess vascular inflammation. Rb-82 PET studies were used to assess changes in left ventricular MFR. A total of 34 participants were enrolled in the study (11 in group 1, 13 in group 2, and 10 controls). A significant drop in the thoracic aorta uptake was observed in the biologic-treated group (Delta TBRmax: - .46 +/- .55) compared to the PsO group treated with non-biologic therapy (Delta TBRmax: .23 +/- .67). Those showing response to biologic agents maintained MFR compared to who showed no response.ConclusionIn a cohort of psoriasis patients treated with biologics, FDG uptake in the thoracic aorta decreased over the study period. Patients who demonstrated a significant anti-inflammatory response on FDG PET imaging maintained their MFR compared to non-responders.

引用

页码：1642 / 1652

页数：11

共 42 条

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