Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report

被引：4

作者：

Goldman, Jason D. ^{[1
,2
,3
]}

Wang, Kai ^{[4
]}

Roltgen, Katharina ^{[5
]}

Nielsen, Sandra C. A. ^{[5
]}

Roach, Jared C. ^{[4
]}

Naccache, Samia N. ^{[6
]}

Yang, Fan ^{[5
]}

Wirz, Oliver F. ^{[5
]}

Yost, Kathryn E. ^{[5
]}

Lee, Ji-Yeun ^{[5
]}

Chun, Kelly ^{[7
]}

Wrin, Terri ^{[8
]}

Petropoulos, Christos J. ^{[8
]}

Lee, Inyoul ^{[4
]}

Fallen, Shannon ^{[4
]}

Manner, Paula M. ^{[2
,9
]}

Wallick, Julie A. ^{[2
,9
]}

Algren, Heather A. ^{[2
,9
]}

Murray, Kim M. ^{[4
]}

Hadlock, Jennifer ^{[2
,4
]}

Chen, Daniel ^{[4
]}

Dai, Chengzhen L. ^{[4
]}

Yuan, Dan ^{[4
]}

Su, Yapeng ^{[4
]}

Jeharajah, Joshua ^{[10
]}

Berrington, William R. ^{[1
,2
]}

Pappas, George P. ^{[11
]}

Nyatsatsang, Sonam T. ^{[1
,2
]}

Greninger, Alexander L. ^{[12
,13
]}

Satpathy, Ansuman T. ^{[5
]}

Pauk, John S. ^{[1
,2
]}

Boyd, Scott D. ^{[5
,14
]}

Heath, James R. ^{[4
]}

机构：

[1] Swedish Med Ctr, Div Infect Dis, Seattle, WA 98122 USA

[2] Providence St Joseph Hlth, Renton, WA 98057 USA

[3] Univ Washington, Div Allergy & Infect Dis, Seattle, WA 98195 USA

[4] Inst Syst Biol, Seattle, WA 98103 USA

[5] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[6] LabCorp, Dept Microbiol, Seattle, WA 98104 USA

[7] LabCorp Esoterix, Calabasas, CA 91301 USA

[8] Monogram Biosci, San Francisco, CA 94080 USA

[9] Swedish Med Ctr, Swedish Ctr Res & Innovat, Seattle, WA 98104 USA

[10] Polyclin, Div Infect Dis, Seattle, WA 98104 USA

[11] Swedish Med Ctr, Div Pulmonol & Crit Care Med, Seattle, WA 98104 USA

[12] Univ Washington, Dept Lab Med & Pathol, Sch Med, Seattle, WA 98109 USA

[13] Fred Hutch, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[14] Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94304 USA

来源：

VACCINES | 2023年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; COVID-19; reinfection; humoral immunity;

D O I：

10.3390/vaccines11010005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recovery from COVID-19 is associated with production of anti-SARS-CoV-2 antibodies, but it is uncertain whether these confer immunity. We describe viral RNA shedding duration in hospitalized patients and identify patients with recurrent shedding. We sequenced viruses from two distinct episodes of symptomatic COVID-19 separated by 144 days in a single patient, to conclusively describe reinfection with a different strain harboring the spike variant D614G. This case of reinfection was one of the first cases of reinfection reported in 2020. With antibody, B cell and T cell analytics, we show correlates of adaptive immunity at reinfection, including a differential response in neutralizing antibodies to a D614G pseudovirus. Finally, we discuss implications for vaccine programs and begin to define benchmarks for protection against reinfection from SARS-CoV-2.

引用

页数：14

共 47 条

[1] Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate [J].

Addetia, Amin ;

Crawford, Katharine H. D. ;

Dingens, Adam ;

Zhu, Haiying ;

Roychoudhury, Pavitra ;

Huang, Meei-Li ;

Jerome, Keith R. ;

Bloom, Jesse D. ;

Greninger, Alexander L. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2020, 58 (11)

[2]

Alvarez-Moreno CA, 2020, TRAVEL MED INFECT DI, V35, DOI 10.1016/j.tmaid.2020.101743

[3] Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility [J].

Arons, M. M. ;

Hatfield, K. M. ;

Reddy, S. C. ;

Kimball, A. ;

James, A. ;

Jacobs, J. R. ;

Taylor, J. ;

Spicer, K. ;

Bardossy, A. C. ;

Oakley, L. P. ;

Tanwar, S. ;

Dyal, J. W. ;

Harney, J. ;

Chisty, Z. ;

Bell, J. M. ;

Methner, M. ;

Paul, P. ;

Carlson, C. M. ;

McLaughlin, H. P. ;

Thornburg, N. ;

Tong, S. ;

Tamin, A. ;

Tao, Y. ;

Uehara, A. ;

Harcourt, J. ;

Clark, S. ;

Brostrom-Smith, C. ;

Page, L. C. ;

Kay, M. ;

Lewis, J. ;

Montgomery, P. ;

Stone, N. D. ;

Clark, T. A. ;

Honein, M. A. ;

Duchin, J. S. ;

Jernigan, J. A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (22) :2081-2090

[4] Cryptic transmission of SARS-CoV-2 in Washington state [J].

Bedford, Trevor ;

Greninger, Alexander L. ;

Roychoudhury, Pavitra ;

Starita, Lea M. ;

Famulare, Michael ;

Huang, Meei-Li ;

Nalla, Arun ;

Pepper, Gregory ;

Reinhardt, Adam ;

Xie, Hong ;

Shrestha, Lasata ;

Nguyen, Truong N. ;

Adler, Amanda ;

Brandstetter, Elisabeth ;

Cho, Shari ;

Giroux, Danielle ;

Han, Peter D. ;

Fay, Kairsten ;

Frazar, Chris D. ;

Ilcisin, Misja ;

Lacombe, Kirsten ;

Lee, Jover ;

Kiavand, Anahita ;

Richardson, Matthew ;

Sibley, Thomas R. ;

Truong, Melissa ;

Wolf, Caitlin R. ;

Nickerson, Deborah A. ;

Rieder, Mark J. ;

Englund, Janet A. ;

Hadfield, James ;

Hodcroft, Emma B. ;

Huddleston, John ;

Moncla, Louise H. ;

Mueller, Nicola F. ;

Neher, Richard A. ;

Deng, Xianding ;

Gu, Wei ;

Federman, Scot ;

Chiu, Charles ;

Duchin, Jeffrey S. ;

Gautom, Romesh ;

Melly, Geoff ;

Hiatt, Brian ;

Dykema, Philip ;

Lindquist, Scott ;

Queen, Krista ;

Tao, Ying ;

Uehara, Anna ;

Tong, Suxiang .

SCIENCE, 2020, 370 (6516) :571-+

[5]

CDC, DUR IS PREC AD COVID

[6]

CDC, CDCS DIAGN TEST COVI

[7]

CDC, DISC TRANSM BAS PREC

[8] A case of COVID-19 Reinfection and Systematic Review of Patterns of Reinfection [J].

Chamblain, Melissa ;

Dawkins, Elissa ;

Lane, Jason ;

Ghany, Reyan ;

Tamariz, Leonardo ;

Palacio, Ana ;

Guzman-Suarez, Belisa .

INFECTIOUS DISEASES IN CLINICAL PRACTICE, 2021, 29 (06) :E409-E411

[9] A strategic approach to COVID-19 vaccine R&D [J].

Corey, Lawrence ;

Mascola, John R. ;

Fauci, Anthony S. ;

Collins, Francis S. .

SCIENCE, 2020, 368 (6494) :948-950

[10] Is novel coronavirus 2019 reinfection possible? Interpreting dynamic SARS-CoV-2 test results [J].

Duggan, Nicole M. ;

Ludy, Stephanie M. ;

Shannon, Bryant C. ;

Reisner, Andrew T. ;

Wilcox, Susan R. .

AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2021, 39 :256.e1-256.e3

← 1 2 3 4 5 →