Inflammation-mediated metabolic regulation in adipose tissue

被引:10
|
作者
Xu, Shujie [1 ]
Lu, Feng [1 ]
Gao, Jianhua [1 ,2 ]
Yuan, Yi [1 ,2 ]
机构
[1] Southern Med Univ, Nanfang Hosp, Dept Plast & Reconstruct Surg, Guangzhou, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Dept Plast & Reconstruct Surg, Guangzhou 510515, Peoples R China
基金
中国国家自然科学基金;
关键词
adipose tissue; inflammation; lipid metabolism; metabolic diseases; ENDOPLASMIC-RETICULUM STRESS; TUMOR-NECROSIS-FACTOR; FATTY-ACID OXIDATION; INSULIN-RESISTANCE; LIPID-METABOLISM; NONALCOHOLIC STEATOHEPATITIS; ADIPOCYTE INFLAMMATION; MACROPHAGE INFILTRATION; GUT MICROBIOTA; GRAFT-SURVIVAL;
D O I
10.1111/obr.13724
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammation of adipose tissue is a prominent characteristic of many metabolic diseases. Lipid metabolism in adipose tissue is consistently dysregulated during inflammation, which is characterized by substantial infiltration by proinflammatory cells and high cytokine concentrations. Adipose tissue inflammation is caused by a variety of endogenous factors, such as mitochondrial dysfunction, reactive oxygen species (ROS) production, endoplasmic reticulum (ER) stress, cellular senescence, ceramides biosynthesis and mediators of lipopolysaccharides (LPS) signaling. Additionally, the gut microbiota also plays a crucial role in regulating adipose tissue inflammation. Essentially, adipose tissue inflammation arises from an imbalance in adipocyte metabolism and the regulation of immune cells. Specific inflammatory signals, including nuclear factor-kappa B (NF-kappa B) signaling, inflammasome signaling and inflammation-mediated autophagy, have been shown to be involved in the metabolic regulation. The pathogenesis of metabolic diseases characterized by chronic inflammation (obesity, insulin resistance, atherosclerosis and nonalcoholic fatty liver disease [NAFLD]) and recent research regarding potential therapeutic targets for these conditions are also discussed in this review.
引用
收藏
页数:17
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