Modulating Antigen Availability in Lymphoid Organs to Shape the Humoral Immune Response to Vaccines

被引：4

作者：

Aung, Aereas ^{[1
,2
,8
]}

Irvine, Darrell J. ^{[3
,4
,5
,6
,7
,9
]}

机构：

[1] Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada

[2] MIT, Koch Inst Integrat Canc Res, Cambridge, MA USA

[3] MIT, Dept Biol Engn, Cambridge, MA USA

[4] Scripps Res Inst, Consortium HIV AIDS Vaccine Dev, La Jolla, CA USA

[5] Ragon Inst Massachusetts Gen Hosp Massachusetts In, Cambridge, MA USA

[6] Howard Hughes Med Inst, Cambridge, MA USA

[7] MIT, Dept Mat Sci & Engn, Cambridge, MA USA

[8] Univ Toronto, Inst Biomed Engn, 164 Coll St,Rosebrugh Bldg,Room 407, Toronto, ON M5S 3E2, Canada

[9] MIT, 500 Main St,Room 76-261, Cambridge, MA 02139 USA

来源：

JOURNAL OF IMMUNOLOGY | 2024年 / 212卷 / 02期

关键词：

SUBCAPSULAR SINUS MACROPHAGES; B-CELL RESPONSES; GERMINAL CENTER INITIATION; DENDRITIC CELLS; IN-VIVO; AFFINITY MATURATION; ANTIBODY-RESPONSES; INFLUENZA-VIRUS; COMPLEMENT; ACTIVATION;

D O I：

10.4049/jimmunol.2300500

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary immune responses following vaccination are initiated in draining lymph nodes, where naive T and B cells encounter Ag and undergo coordinated steps of activation. For humoral immunity, the amount of Ag present over time, its localization to follicles and follicular dendritic cells, and the Ag's structural state all play important roles in determining the subsequent immune response. Recent studies have shown that multiple elements of vaccine design can impact Ag availability in lymphoid tissues, including the choice of adjuvant, physical form of the immunogen, and dosing kinetics. These vaccine design elements affect the transport of Ag to lymph nodes, Ag's localization in the tissue, the duration of Ag availability, and the structural integrity of the Ag. In this review, we discuss these findings and their implications for engineering more effective vaccines, particularly for difficult to neutralize pathogens. The Journal of Immunology, 2024, 212: 171-178.

引用

页码：171 / 178

页数：9

共 105 条

[1] Rate of Immune Complex Cycling in Follicular Dendritic Cells Determines the Extent of Protecting Antigen Integrity and Availability to Germinal Center B Cells [J].