Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms

被引：0

作者：

Aranda, Selena ^{[1
,2
,3
,4
]}

Jimenez, Esther ^{[4
,5
,6
]}

Canales-Rodriguez, Erick J. ^{[4
,7
,8
]}

Verdolini, Norma ^{[4
,5
,7
]}

Alonso, Silvia ^{[4
,5
]}

Sepulveda, Esteban ^{[1
,2
,3
,4
]}

Julia, Antonio ^{[9
]}

Marsal, Sara ^{[9
]}

Bobes, Julio ^{[4
,10
,11
,12
,13
]}

Saiz, Pilar A. ^{[4
,10
,11
,12
,13
]}

Garcia-Portilla, Paz ^{[4
,10
,11
,12
,13
]}

Menchon, Jose M. ^{[4
,14
,15
]}

Crespo, Jose M. ^{[4
,14
,15
]}

Gonzalez-Pinto, Ana ^{[4
,6
,16
]}

Perez, Victor ^{[4
,17
,18
,19
]}

Arango, Celso ^{[4
,20
,21
,22
]}

Sierra, Pilar ^{[23
,24
]}

Sanjuan, Julio ^{[4
,24
]}

Pomarol-Clotet, Edith ^{[4
,7
]}

Vieta, Eduard ^{[4
,5
]}

Vilella, Elisabet ^{[1
,2
,3
,4
]}

机构：

[1] Inst Invest Sanitaria Pere Virgili CERCA, Reus, Spain

[2] Hosp Univ Inst Pere Mata, Reus, Spain

[3] Univ Rovira i Virgili, Reus, Spain

[4] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[5] Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Spain

[6] Univ Basque Country UPV EHU, Dept Psychiat, Vitoria, Spain

[7] FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain

[8] Ecole Polytech Fed Lausanne EPFL, Signal Proc Lab LTS5, Lausanne, Switzerland

[9] Vall dHebron Res Inst, Rheumatol Res Grp, Barcelona, Spain

[10] Univ Oviedo, Dept Psychiat, Oviedo, Spain

[11] nstituto Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain

[12] Inst Univ Neurociencias Principado Asturias INEURO, Oviedo, Spain

[13] Serv Salud Principado Asturias SESPA Oviedo, Oviedo, Spain

[14] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain

[15] Univ Barcelona, Dept Clin Sci, Barcelona, Spain

[16] Univ Basque Country, Araba Univ Hosp, Bioaraba Res Inst, Vitoria, Spain

[17] Hosp Mar, Mental Hlth Inst, Barcelona, Spain

[18] Hosp del Mar Invest Med, Neurosci Res Unit, Barcelona, Spain

[19] Pompeu Fabra Univ, Dept Expt & Hlth Sci, Barcelona, Spain

[20] Inst Psychiat & Mental Hlth, Madrid, Spain

[21] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[22] Univ Complutense, Madrid, Spain

[23] La Fe Univ & Polytech Hosp, Valencia, Spain

[24] Univ Valencia, Sch Med, Dept Psychiat, Valencia, Spain

来源：

MOLECULAR PSYCHIATRY | 2024年 / 29卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

GENOME-WIDE ASSOCIATION; DOMAIN RECEPTOR 1; RATING-SCALE; GENE; SUSCEPTIBILITY; EXPRESSION; EPISTASIS; COGNITION;

D O I：

10.1038/s41380-024-02480-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DDR1 locus is associated with the diagnosis of schizophrenia and with processing speed in patients with schizophrenia and first-episode psychosis. Here, we investigated whether DDR1 variants are associated with bipolar disorder (BD) features. First, we performed a case-control association study comparing DDR1 variants between patients with BD and healthy controls. Second, we performed linear regression analyses to assess the associations of DDR1 variants with neurocognitive domains and psychosocial functioning. Third, we conducted a mediation analysis to explore whether neurocognitive impairment mediated the association between DDR1 variants and psychosocial functioning in patients with BD. Finally, we studied the association between DDR1 variants and white matter microstructure. We did not find any statistically significant associations in the case-control association study; however, we found that the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse neurocognitive performance in patients with BD with psychotic symptoms. In addition, the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse psychosocial functioning through processing speed. We did not find correlations between white matter microstructure abnormalities and the neurocognitive domains associated with the combined genotypes rs1264323AA-rs2267641AC/CC. Overall, the results suggest that DDR1 may be a marker of worse neurocognitive performance and psychosocial functioning in patients with BD, specifically those with psychotic symptoms.

引用

页码：2050 / 2058

页数：9

共 23 条

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