Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective

被引：4

作者：

Husereau, Don ^{[1
]}

Bombard, Yvonne ^{[2
,3
]}

Stockley, Tracy ^{[4
,5
]}

Carter, Michael ^{[6
]}

Davey, Scott ^{[7
,8
,9
,10
]}

Lemaire, Diana ^{[11
]}

Nohr, Erik ^{[12
,13
]}

Park, Paul ^{[14
]}

Spatz, Alan ^{[15
,16
,17
,18
]}

Williams, Christine ^{[7
,11
]}

Pollett, Aaron ^{[19
,20
]}

Lo, Bryan ^{[21
]}

Yip, Stephen ^{[22
]}

El Hallani, Soufiane ^{[23
]}

Feilotter, Harriet ^{[7
,11
]}

机构：

[1] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON K1G 5Z3, Canada

[2] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON M5T 3M6, Canada

[3] Unity Hlth Toronto, Michaels Hosp, Li Ka Shing Knowledge Inst, Genom Hlth Serv Res Program, Toronto, ON M5B 1T8, Canada

[4] Univ Hlth Network, Lab Med Program, Div Clin Lab Genet, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada

[5] Univ Toronto, Dept Lab Med & Pathobiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

[6] Nova Scotia Hlth Author Cent Zone, Dept Pathol & Lab Med, Halifax, NS B3H 1V8, Canada

[7] Queens Univ, Dept Pathol & Mol Med, Kingston, ON K7L 3N6, Canada

[8] Queens Univ, Div Canc Biol & Genet, Canc Res Inst, Kingston, ON K7L 3N6, Canada

[9] Queens Univ, Canc Res Inst, Dept Biomed & Mol Sci, Kingston, ON K7L 2V7, Canada

[10] Queens Univ, Canc Res Inst, Dept Biomed & Mol Sci, Kingston, ON K7L 2V7, Canada

[11] Ontario Inst Canc Res, 661 Univ Ave, Toronto, ON M5G 0A3, Canada

[12] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB T2N 1N4, Canada

[13] Foothills Med Ctr, Alberta Precis Labs, 1403 29 St NW, Calgary, AB T2N 2T9, Canada

[14] Univ Manitoba, Rady Fac Hlth Sci, Dept Pathol, Winnipeg, MB R3A 1R9, Canada

[15] McGill Univ, Div Pathol, Hlth Ctr, 1001 Decarie Blvd, Montreal, PQ H4A 3J, Canada

[16] OPTILAB MUHC, 1001 Decarie Blvd, Montreal, PQ H4A 3J, Canada

[17] Dept Lab Med, 1001 Decarie Blvd, Montreal, PQ H4A 3J, Canada

[18] Lady Davis Inst, Res Mol Pathol Ctr, 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada

[19] Sinai Hlth Syst, Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[20] Univ Toronto, Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[21] Ottawa Gen Hosp, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada

[22] Univ British Columbia, Fac Med, Dept Pathol & Lab Med, Vancouver, BC V6T 1Z7, Canada

[23] Univ Alberta, Fac Med & Dent, Dept Lab Med & Pathol, Alberta Precis Lab, Edmonton, AB T6G 2R7, Canada

来源：

CURRENT ONCOLOGY | 2023年 / 30卷 / 11期

关键词：

genomic biomarkers; clinical utility; clinical validity; analytic validity; health technology assessment; RECOMMENDATIONS; CHALLENGES; DEVICES;

D O I：

10.3390/curroncol30110700

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genome-based testing in oncology is a rapidly expanding area of health care that is the basis of the emerging area of precision medicine. The efficient and considered adoption of novel genomic medicine testing is hampered in Canada by the fragmented nature of health care oversight as well as by lack of clear and transparent processes to support rapid evaluation, assessment, and implementation of genomic tests. This article provides an overview of some key barriers and proposes approaches to addressing these challenges as a potential pathway to developing a national approach to genomic medicine in oncology.

引用

页码：9660 / 9669

页数：10

共 38 条

[1]

Allen CJ, 2022, ANN SURG ONCOL, V29, P6537, DOI 10.1245/s10434-022-11534-z

[2]

Andrews LB., 1994, ASSESSING GENETIC RI

[3]

[Anonymous], Recommendation Report for Ontario's Clinical Genetic Services

[4]

[Anonymous], 2020, Ontario Pathway Towards Innovation in Cancer Care (OPTICC)

[5]

[Anonymous], 2008, Ensuring Access to High Quality Molecular Oncology Laboratory Testing and Clinical Cancer Genetic Services in Ontario

[6]

Report of the Molecular Oncology Task Force

[7] Genomic Testing for Human Health and Disease Across the Life Cycle: Applications and Ethical, Legal, and Social Challenges [J].

Bilkey, Gemma A. ;

Burns, Belinda L. ;

Coles, Emily P. ;

Bowman, Faye L. ;

Beilby, John P. ;

Pachter, Nicholas S. ;

Baynam, Gareth ;

Dawkins, Hugh J. S. ;

Nowak, Kristen J. ;

Weeramanthri, Tarun S. .

FRONTIERS IN PUBLIC HEALTH, 2019, 7

[8] Patients' perceptions of gene expression profiling in breast cancer treatment decisions [J].

Bombard, Y. ;

Rozmovits, L. ;

Trudeau, M. E. ;

Leighl, N. B. ;

Deal, K. ;

Marshall, D. A. .

CURRENT ONCOLOGY, 2014, 21 (02) :E203-E211

[9] Translating personalized genomic medicine into clinical practice: evidence, values, and health policy [J].

Bombard, Yvonne .

GENOME, 2015, 58 (12) :491-497

[10] Translating Genomics in Cancer Care [J].

Bombard, Yvonne ;

Bach, Peter B. ;

Offit, Kenneth .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2013, 11 (11) :1343-1353

← 1 2 3 4 →