Microbiome-based therapies for periodontitis and peri-implantitis

被引：13

作者：

Wei, Xindi ^{[1
]}

Qian, Shujiao ^{[1
]}

Yang, Yijie ^{[1
]}

Mo, Jiaji ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ Sch Med, Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Shanghai Res Inst Stomatol,Dept Oral & Maxillo fac, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Oral & Maxillo facial Implantol, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China

来源：

ORAL DISEASES | 2024年 / 30卷 / 05期

关键词：

microbiome-based therapy; oral microbiota; peri-implantitis; periodontitis; probiotic; LACTOBACILLUS-SALIVARIUS; PHAGE THERAPY; PROBIOTICS; HEALTH; TRANSPLANTATION; BIOFILM; RHAMNOSUS; DYSBIOSIS; MODEL;

D O I：

10.1111/odi.14782

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectivesPeriodontitis and peri-implantitis are oral infectious-inflammatory diseases associated with oral microbial dysbiosis. Microbiome-based therapies, characterized by manipulation of the microbiota, are emerging as promising therapeutic approaches to resolve the microbial dysbiosis and associated dysregulation of immune system. This review aims at summarizing recent progress on microbiome-based therapies in periodontitis and peri-implantitis, promoting a further understanding of the related therapeutic mechanisms.Subjects and MethodsPertinent literatures focused on microbiome-based therapies for periodontitis and peri-implantitis are obtained from PubMed and Web of Science.ResultsIn this article, we review the roles and therapeutic mechanisms of four microbiome-based therapies, including probiotics, postbiotics, predatory bacteria and phages, and microbiota transplantation, in the management of periodontitis and peri-implantitis. Challenges facing this field are also discussed, highlighting the areas that require more attention and investigation.ConclusionsMicrobiome-based therapies may serve as effective treatment for periodontitis and peri-implantitis. This review presents a new viewpoint to this field.

引用

页码：2838 / 2857

页数：20

共 127 条

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