Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination

被引：6

作者：

Messina, Nicole L. ^{[1
,2
]}

Sperotto, Mariana G. ^{[3
,4
]}

Puga, Marco A. M. ^{[3
,4
]}

da Silva, Patricia V. ^{[3
,4
]}

de Oliveira, Roberto D. ^{[5
,6
]}

Moore, Cecilia L. ^{[7
]}

Pittet, Laure F. ^{[1
,2
,8
]}

Jamieson, Tenaya ^{[1
]}

Dalcolmo, Margareth ^{[9
,10
]}

dos Santos, Glauce ^{[11
]}

Jardim, Bruno ^{[12
]}

Lacerda, Marcus V. G. ^{[12
]}

Curtis, Nigel ^{[1
,2
,8
]}

Croda, Julio ^{[3
,4
,13
]}

机构：

[1] Murdoch Childrens Res Inst, Infect Dis Grp, Infect & Immun Theme, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Paediat, Parkville, Vic, Australia

[3] Univ Fed Mato Grosso, Sch Med, Campo Grande, MS, Brazil

[4] Oswaldo Cruz Fdn Mato Grosso, Campo Grande, MS, Brazil

[5] Univ Estadual Mato Grosso do Sul, Dourados, MS, Brazil

[6] Fed Univ Grande Dourados, Dourados, Brazil

[7] Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Parkville, Vic, Australia

[8] Royal Childrens Hosp Melbourne, Infect Dis, Parkville, Vic, Australia

[9] Oswaldo Cruz Fdn Minist Hlth, Helio Fraga Reference Ctr, Rio De Janeiro, RJ, Brazil

[10] Pontifical Catholic Univ Rio De Janeiro, Rio De Janeiro, RJ, Brazil

[11] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, Rio De Janeiro, RJ, Brazil

[12] Fundacao Med Trop Doutor Heitor Vieira Dourado, Inst Clin Res Carlos Borborema, Manaus, Amazonas, Brazil

[13] Yale Sch Publ Hlth, New Haven, CT 06510 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

瑞士国家科学基金会; 英国医学研究理事会;

关键词：

vaccine; COVID-19; antibody; ChAdOx1-S; CoronaVac; BCG; MYCOBACTERIA; PROTECTION; INDUCTION; EFFICACY;

D O I：

10.3389/fimmu.2023.1172851

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.

引用

页数：8

共 58 条

[1] SARS-CoV-2 Antibody Response in Persons with Past Natural Infection [J].

Anichini, Gabriele ;

Terrosi, Chiara ;

Gandolfo, Claudia ;

Gori Savellini, Gianni ;

Fabrizi, Simonetta ;

Miceli, Giovanni B. ;

Cusi, M. Grazia .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (01) :90-92

[2] BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity [J].

Arts, Rob J. W. ;

Moorlag, Simone J. C. F. M. ;

Novakovic, Boris ;

Li, Yang ;

Wang, Shuang-Yin ;

Oosting, Marije ;

Kumar, Vinod ;

Xavier, Ramnik J. ;

Wijmenga, Cisca ;

Joosten, Leo A. B. ;

Reusken, Chantal B. E. M. ;

Benn, Christine S. ;

Aaby, Peter ;

Koopmans, Marion P. ;

Stunnenberg, Hendrik G. ;

van Crevel, Reinout ;

Netea, Mihai G. .

CELL HOST & MICROBE, 2018, 23 (01) :89-+

[3] Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes [J].

Bannister, Samantha ;

Kim, Bowon ;

Dominguez-Andres, Jorge ;

Kilic, Gizem ;

Ansell, Brendan R. E. ;

Neeland, Melanie R. ;

Moorlag, Simone J. C. F. M. ;

Matzaraki, Vasiliki ;

Vlahos, Amanda ;

Shepherd, Rebecca ;

Germano, Susie ;

Bahlo, Melanie ;

Messina, Nicole L. ;

Saffery, Richard ;

Netea, Mihai G. ;

Curtis, Nigel ;

Novakovic, Boris .

SCIENCE ADVANCES, 2022, 8 (31)

[4] Comparison of SARS-CoV-2 anti-spike receptor binding domain IgG antibody responses after CoronaVac, BNT162b2, ChAdOx1 COVID-19 vaccines, and a single booster dose: a prospective, longitudinal population-based study [J].

Barin, Burc ;

Kasap, Ulus ;

Selcuk, Ferda ;

Volkan, Ender ;

Uluckan, Ozge .

LANCET MICROBE, 2022, 3 (04) :E274-E283

[5] Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis [J].

Brandt, L ;

Cunha, JF ;

Olsen, AW ;

Chilima, B ;

Hirsch, P ;

Appelberg, R ;

Andersen, P .

INFECTION AND IMMUNITY, 2002, 70 (02) :672-678

[6] The COVID-19 vaccine development: A pandemic paradigm [J].

Carneiro, Diego C. ;

Sousa, Jessica D. ;

Monteiro-Cunha, Joana P. .

VIRUS RESEARCH, 2021, 301

[7] Spatiotemporal pattern of COVID-19 spread in Brazil [J].

Castro, Marcia C. ;

Kim, Sun ;

Barberia, Lorena ;

Ribeiro, Ana Freitas ;

Gurzenda, Susie ;

Ribeiro, Karina Braga ;

Abbott, Erin ;

Blossom, Jeffrey ;

Rache, Beatriz ;

Singer, Burton H. .

SCIENCE, 2021, 372 (6544) :821-+

[8] BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial [J].

Claus, Juana ;

ten Doesschate, Thijs ;

Gumbs, Cheyenne ;

van Werkhoven, Cornelis H. ;

van der Vaart, Thomas W. ;

Janssen, Axel B. ;

Smits, Gaby ;

van Binnendijk, Rob ;

van der Klis, Fiona ;

van Baarle, Debbie ;

Paganelli, Fernanda L. ;

Leavis, Helen ;

Verhagen, Lilly M. ;

Joosten, Simone A. ;

Bonten, Marc J. M. ;

Netea, Mihai G. ;

van de Wijgert, Janneke H. H. M. .

MBIO, 2023, 14 (02)

[9] A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection [J].

Counoupas, Claudio ;

Johansen, Matt D. ;

Stella, Alberto O. ;

Nguyen, Duc H. ;

Ferguson, Angela L. ;

Aggarwal, Anupriya ;

Bhattacharyya, Nayan D. ;

Grey, Alice ;

Hutchings, Owen ;

Patel, Karishma ;

Siddiquee, Rezwan ;

Stewart, Erica L. ;

Feng, Carl G. ;

Hansbro, Nicole G. ;

Palendira, Umaimainthan ;

Steain, Megan C. ;

Saunders, Bernadette M. ;

Low, Jason K. K. ;

Mackay, Joel P. ;

Kelleher, Anthony D. ;

Britton, Warwick J. ;

Turville, Stuart G. ;

Hansbro, Philip M. ;

Triccas, James A. .

NPJ VACCINES, 2021, 6 (01)

[10] The impact of BCG dose and revaccination on trained immunity [J].

Debisarun, Priya A. ;

Kilic, Gizem ;

de Bree, L. Charlotte J. ;

Pennings, Lian J. ;

van Ingen, Jakko ;

Benn, Christine S. ;

Aaby, Peter ;

Dijkstra, Helga ;

Lemmers, Heidi ;

Dominguez-Andres, Jorge ;

van Crevel, Reinout ;

Netea, Mihai G. .

CLINICAL IMMUNOLOGY, 2023, 246

← 1 2 3 4 5 6 →