Direct evidence for the involvement of intestinal reactive oxygen species in the progress of depression via the gut-brain axis

被引：10

作者：

Ikeda, Yutaka ^{[1
]}

Saigo, Naoki ^{[1
]}

Nagasaki, Yukio ^{[1
,2
,3
]}

机构：

[1] Univ Tsukuba, Grad Sch Pure & Appl Sci, Dept Mat Sci, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan

[2] Univ Tsukuba, Masters Sch Med Sci, Grad Sch Comprehens Human Sci, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan

[3] Univ Tsukuba, Ctr Res Isotopes & Environm Dynam CRiED, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058573, Japan

来源：

BIOMATERIALS | 2023年 / 295卷

基金：

日本学术振兴会;

关键词：

Depression; Gut-brain axis; Oxidative stress; Polymer-based antioxidant; TEMPO; Leaky gut; INFLAMMATION; STRESS; METAANALYSIS;

D O I：

10.1016/j.biomaterials.2023.122053

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Depression is a serious global social problem. Various therapeutic drugs have been developed based on the monoamine hypothesis; however, treatment-resistant depression is a common clinical issue. Recently, the gutbrain axis, which is associated with the hypothesis that the intestinal environment affects the brain, has garnered significant interest, and several studies have attempted to treat brain disorders based on this axis. These attempts include fecal transplantation, probiotics and prebiotics. In this study, we focused on intestinal reactive oxygen species (ROS) because excessive ROS levels disturb the intestinal environment. To elucidate the impact of scavenging intestinal ROS on depression treatment via the gut-brain axis, a novel polymer-based antioxidant (siSMAPoTN), which was distributed only in the intestine and did not diffuse into the whole body after oral administration, was used. siSMAPoTN selectively scavenged intestinal ROS and protected the intestinal environment from damage caused by chronic restraint stress (CRS). In addition, siSMAPoTN suppressed physiological and behavioral depression-related symptoms in the CRS mouse model.

引用

页数：10