Arachidonic Acid Pathways and Male Fertility: A Systematic Review

被引：7

作者：

Hoxha, Malvina ^{[1
]}

Barbonetti, Arcangelo ^{[2
]}

Zappacosta, Bruno ^{[1
]}

机构：

[1] Catholic Univ Our Lady Good Counsel, Fac Pharm, Dept Chem Toxicol & Pharmacol Evaluat Drugs, Tirana 1000, Albania

[2] Univ Aquila, Dept Life Hlth & Environm Sci, Androl Unit, I-67100 Laquila, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 09期

关键词：

male fertility; arachidonic acid pathway; prostaglandins; PROSTAGLANDIN-D-SYNTHASE; TESTICULAR PERITUBULAR CELLS; SEMINAL PROSTAGLANDINS; ANTIINFLAMMATORY DRUGS; HUMAN SPERMATOZOA; ACETYLSALICYLIC-ACID; MILD ANALGESICS; SPERM FUNCTION; ASPIRIN; SEMEN;

D O I：

10.3390/ijms24098207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arachidonic acid (AA) is a polyunsaturated fatty acid that is involved in male fertility. Human seminal fluid contains different prostaglandins: PGE (PGE(1) and PGE(2)), PGF(2a), and their specific 19-hydroxy derivatives, 18,19-dehydro derivatives of PGE(1) and PGE(2). The objective of this study is to synthesize the available literature of in vivo animal studies and human clinical trials on the association between the AA pathway and male fertility. PGE is significantly decreased in the semen of infertile men, suggesting the potential for exploitation of PGE agonists to improve male fertility. Indeed, ibuprofen can affect male fertility by promoting alterations in sperm function and standard semen parameters. The results showed that targeting the AA pathways could be an attractive strategy for the treatment of male fertility.

引用

页数：18

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