Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1-jk]carbazoles by Sequential C-N and C-C Bond Formation

被引：2

作者：

Azizzade, Meysam ^{[1
]}

Ranjbar, Parviz Rashidi ^{[1
]}

Sajadi, Akram ^{[1
]}

机构：

[1] Univ Tehran, Sch Chem, Coll Sci, Tehran 141556455, Iran

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 11期

关键词：

PROPARGYL ALCOHOLS; CYCLOADDITION; ACTIVATION; INDOLES; ALKYNES; ACCESS;

D O I：

10.1021/acs.orglett.3c00244

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of propargyl alcohols from simple, cheap, and easily accessible ketones has also been developed during the one-pot synthesis of [3,2,1-jk]carbazoles. ??? R1 ??? Facile access to raw materials ??? Ligand-, Base-, and Silver-free reaction ??? One-pot tandem reaction ??? Up to 97% isolated yield, grain scalable R2,` R3 Pd/C R1 AromatIzatl n R1

引用

页码：1823 / 1828

页数：6

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