Retinopathy of prematurity

被引:59
作者
Dammann, Olaf [1 ,2 ,3 ]
Hartnett, M. Elizabeth [4 ]
Stahl, Andreas [5 ]
机构
[1] Tufts Univ, Dept Publ Hlth & Community Med, Sch Med, Boston, MA 02111 USA
[2] Hannover Med Sch, Dept Obstet & Gynecol, Hannover, Germany
[3] Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway
[4] Univ Utah Hlth, John A Moran Eye Ctr, Dept Ophthalmol & Visual Sci, Salt Lake City, UT USA
[5] Univ Med Greifswald, Dept Ophthalmol Greifswald, Mecklenburg Vorpommern, Germany
关键词
BEVACIZUMAB; BORN; RANIBIZUMAB; MECHANISMS; EFFICACY; OUTCOMES; THERAPY; INFANTS; SAFETY;
D O I
10.1111/dmcn.15468
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Retinopathy of prematurity (ROP) is a devastating neurovascular disease of the retina in newborn infants that can lead to vision deficits or even blindness. In this concise review we discuss our current knowledge about diagnosis, etiology, pathogenesis, intervention, and outcomes of the disease. Major advancements have been made both in categorizing the disease in the new International Classification of Retinopathy of Prematurity, Third Edition classification and in treating severe ROP with anti-vascular endothelial growth factor (VEGF) agents. New development always creates new questions and opens up new areas of research. We will discuss in this review both the benefits and downsides of the new anti-VEGF treatment approaches in ROP, especially in light of our improved understanding of the underlying ROP pathophysiology. We also offer pointers to areas where more research is needed.
引用
收藏
页码:625 / 631
页数:7
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