Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

被引:1
|
作者
Zumbi, Crystal Ngofi [1 ]
Pan, Chun-Hsu [2 ,3 ]
Huang, Hui -Yu [4 ]
Wu, Chieh-Hsi [2 ,3 ]
机构
[1] Taipei Med Univ, Coll Pharm, Program Clin Drug Dev Herbal Med, Taipei 11031, Taiwan
[2] Taipei Med Univ, Coll Pharm, Program Drug Discovery & Dev Ind, Taipei 11031, Taiwan
[3] Taipei Med Univ, Sch Pharm, Taipei 11031, Taiwan
[4] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan
关键词
Ascophyllum nodosum; Fucus vesiculosus; PTEN/PI3K/AKT; Restenosis; Macrophage; Vascular smooth muscle cells; Gut microbiota; MUSCLE-CELL-PROLIFERATION; GUT MICROBIOTA; GROWTH-FACTOR; NEOINTIMAL HYPERPLASIA; TUMOR-SUPPRESSOR; RISK-FACTORS; EXPRESSION; PTEN; MACROPHAGES; RESPONSES;
D O I
10.26599/FSHW.2022.9250222
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Restenosis is a common complication following coronary angioplasty. The traditional use of seaweeds for health benefits has increasingly been explored, however few studies exist reporting its protective effects on the development of restenosis and gut dysbiosis. The aim of this study was to investigate the potential of seaweed extracts (SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells (vSMCs). 16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured rats. As indicated by the results, SE significantly inhibited the progression of intimal hyperplasia in vivo, attenuated inflammation in macrophages and could inhibit the proliferation, dedifferentiation and migration of vSMCs. It was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in vSMCs. Meanwhile, according to the 16S rRNA gene sequencing analysis, supplementation with SE modulated gut microbiota composition in injured rats. In conclusion, SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码:1711 / 1728
页数:18
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