Prognostic impact of pretreatment cell-free DNA concentration in newly diagnosed peripheral T-cell lymphomas

被引：0
|
作者：
Fardella, E. [1 ]
Zanirato, G. [2 ]
Magni, M. [2 ]
Caldarelli, N. [1 ]
Chiappella, A. [2 ]
Dodero, A. [2 ]
Ljevar, S. [3 ]
Orsucci, L. [4 ]
Re, A. [5 ]
Usai, S. V. [6 ]
Stefoni, V. [7 ]
Castellino, C. [8 ]
Rossi, F. G. [9 ]
Pinto, A. [10 ]
Carniti, C. [2 ]
Corradini, P. [1 ,2 ]
机构：
[1] Univ Milan, Milan, Italy
[2] Fdn IRCCS Ist Nazl Tumori, Div Hematol & Stem Cell Transplantat, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Unit Biostat Clin Res, Milan, Italy
[4] Azienda Osped & Univ Citta Salute & Sci, Div Hematol, Turin, Italy
[5] ASST Spedali Civili Brescia, Hematol Div, Brescia, Italy
[6] Osped Oncol Armando Businco, Hematol Unit, Cagliari, Italy
[7] Univ Bologna, Inst Hematol Seragnoli, Bologna, Italy
[8] Azienda Osped S Croce & Carle, Div Hematol, Cuneo, Italy
[9] Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Div Hematol, Milan, Italy
[10] Fdn G Pascale, IRCCS Ist Nazl Tumori, Hematol Oncol & Stem Cell Transplantat Unit, Naples, Italy
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期
关键词：
DNA prognosis; haematological malignancies; prognostic factors; T-cell lymphoma; CANCER;
D O I：
10.1111/bjh.19280
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Peripheral T-cell lymphomas (PTCLs) have a poor prognosis and, to date, there are no reliable predictive biomarkers of response. In this work we explored the prognostic impact of cell-free DNA (cfDNA) concentration in 75 newly diagnosed patients enrolled in a prospective multicenter study. Pre-treatment cfDNA was strongly associated with clinical risk factors and was identified as a superior predictor for shorter progression-free survival in multivariable analysis, outweighing canonical risk parameters. Furthermore, we identified a cfDNA value above which survival worsens. In conclusion, pre-treatment cfDNA concentration represents an easily usable predictive biomarker that is highly associated with survival of PTCL patients.
引用
收藏
页码：1752 / 1756
页数：5
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