Prognostic impact of pretreatment cell-free DNA concentration in newly diagnosed peripheral T-cell lymphomas

被引：0

作者：

Fardella, E. ^{[1
]}

Zanirato, G. ^{[2
]}

Magni, M. ^{[2
]}

Caldarelli, N. ^{[1
]}

Chiappella, A. ^{[2
]}

Dodero, A. ^{[2
]}

Ljevar, S. ^{[3
]}

Orsucci, L. ^{[4
]}

Re, A. ^{[5
]}

Usai, S. V. ^{[6
]}

Stefoni, V. ^{[7
]}

Castellino, C. ^{[8
]}

Rossi, F. G. ^{[9
]}

Pinto, A. ^{[10
]}

Carniti, C. ^{[2
]}

Corradini, P. ^{[1
,2
]}

机构：

[1] Univ Milan, Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Div Hematol & Stem Cell Transplantat, Milan, Italy

[3] Fdn IRCCS Ist Nazl Tumori, Unit Biostat Clin Res, Milan, Italy

[4] Azienda Osped & Univ Citta Salute & Sci, Div Hematol, Turin, Italy

[5] ASST Spedali Civili Brescia, Hematol Div, Brescia, Italy

[6] Osped Oncol Armando Businco, Hematol Unit, Cagliari, Italy

[7] Univ Bologna, Inst Hematol Seragnoli, Bologna, Italy

[8] Azienda Osped S Croce & Carle, Div Hematol, Cuneo, Italy

[9] Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Div Hematol, Milan, Italy

[10] Fdn G Pascale, IRCCS Ist Nazl Tumori, Hematol Oncol & Stem Cell Transplantat Unit, Naples, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2024年 / 204卷 / 05期

关键词：

DNA prognosis; haematological malignancies; prognostic factors; T-cell lymphoma; CANCER;

D O I：

10.1111/bjh.19280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral T-cell lymphomas (PTCLs) have a poor prognosis and, to date, there are no reliable predictive biomarkers of response. In this work we explored the prognostic impact of cell-free DNA (cfDNA) concentration in 75 newly diagnosed patients enrolled in a prospective multicenter study. Pre-treatment cfDNA was strongly associated with clinical risk factors and was identified as a superior predictor for shorter progression-free survival in multivariable analysis, outweighing canonical risk parameters. Furthermore, we identified a cfDNA value above which survival worsens. In conclusion, pre-treatment cfDNA concentration represents an easily usable predictive biomarker that is highly associated with survival of PTCL patients.

引用

页码：1752 / 1756

页数：5

共 50 条

[21] Phase II study of HCVIDD/MA in patients with newly diagnosed peripheral T-cell lymphoma
Chihara, Dai
Pro, Barbara
Loghavi, Sanam
Miranda, Roberto N.
Medeiros, L. Jeffrey
Fanale, Michelle A.
Hagemeister, Fredrick B.
Fayad, Luis E.
Romaguera, Jorge E.
Samaniego, Felipe
Neelapu, Sattva S.
Younes, Anas
Fowler, Nathan H.
Rodriguez, M. Alma
Wang, Michael
Kwak, Larry W.
McLaughlin, Peter
Dang, Nam H.
Oki, Yasuhiro
BRITISH JOURNAL OF HAEMATOLOGY, 2015, 171 (04) : 509 - 516
[22] Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review
Cervena, Klara
Vodicka, Pavel
Vymetalkova, Veronika
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2019, 781 : 100 - 129
[23] Plasma cell-free DNA is a prognostic biomarker for survival in patients with aggressive non-Hodgkin lymphomas
Hur, Joon Young
Kim, Yeon Jeong
Yoon, Sang Eun
Son, Dae-Soon
Park, Woong-Yang
Kim, Seok Jin
Park, Donghyun
Kim, Won Seog
ANNALS OF HEMATOLOGY, 2020, 99 (06) : 1293 - 1302
[24] Comparison of the NCCN-IPI, the IPI and PIT scores as prognostic tools in peripheral T-cell lymphomas
Ellin, Fredrik
Maurer, Matthew J.
Srour, Line
Farooq, Umar
Jerkeman, Mats
Connors, Joseph M.
Smedby, Karin E.
Bennani, N. Nora
Ansell, Stephen M.
Slack, Graham W.
Cerhan, James R.
Relander, Thomas
Feldman, Andrew L.
Savage, Kerry J.
BRITISH JOURNAL OF HAEMATOLOGY, 2019, 186 (03) : E24 - E27
[25] The International Prognostic Index determines the outcome of patients with nodal mature T-cell lymphomas
Sonnen, R
Schmidt, WP
Müller-Hermelink, HK
Schmitz, N
BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (03) : 366 - 372
[26] Diagnostic and Prognostic Value of Circulating Cell-Free DNA for Cholangiocarcinoma
Wintachai, Preawwalee
Lim, Jing Quan
Techasen, Anchalee
Lert-Itthiporn, Worachart
Kongpetch, Sarinya
Loilome, Watcharin
Chindaprasirt, Jarin
Titapun, Attapol
Namwat, Nisana
Khuntikeo, Narong
Jusakul, Apinya
DIAGNOSTICS, 2021, 11 (06)
[27] The future of cell-free DNA testing to guide therapeutic decisions in B-cell lymphomas
Condoluci, Adalgisa
Rossi, Davide
CURRENT OPINION IN HEMATOLOGY, 2019, 26 (04) : 281 - 287
[28] Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma
Nakamura, Nobuhiko
Kanemura, Nobuhiro
Lee, Shin
Fujita, Kei
Morishita, Tetsuji
Takada, Eri
Shibata, Yuhei
Kasahara, Senji
Goto, Hideko
Fukuno, Kenji
Hara, Takeshi
Yamada, Toshiki
Sawada, Michio
Tsurumi, Hisashi
Shimizu, Masahito
LEUKEMIA & LYMPHOMA, 2022, 63 (06) : 1323 - 1330
[29] Digital Pathology for the Validation of Tissue Microarrays in Peripheral T-cell Lymphomas
Pedersen, Martin B.
Riber-Hansen, Rikke
Nielsen, Patricia S.
Bendix, Knud
Hamilton-Dutoit, Stephen J.
D'Amore, Francesco
Steiniche, Torben
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2014, 22 (08) : 577 - 584
[30] Cell-free DNA concentration and integrity as a screening tool for cancer
Zaher, Ebtsam R.
Anwar, Medhat M.
Kohail, Hanaa M. A.
El-Zoghby, Safinaz M.
Abo-El-Eneen, Marwa S.
INDIAN JOURNAL OF CANCER, 2013, 50 (03) : 175 - 183

← 1 2 3 4 5 →