Five-year changes in macular thickness in the elderly population: A cohort study

被引:1
作者
Hashemi, Hassan [1 ]
Khabazkhoob, Mehdi [2 ]
Heydarian, Samira [3 ]
Emamian, Mohammad Hassan [4 ]
Fotouhi, Akbar [5 ]
机构
[1] Noor Eye Hosp, Noor Res Ctr Ophthalm Epidemiol, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Basic Sci, Tehran, Iran
[3] Mazandaran Univ Med Sci, Sch Allied Med Sci, Dept Rehabil Sci, Sari, Iran
[4] Shahroud Univ Med Sci, Ophthalm Epidemiol Res Ctr, Shahroud, Iran
[5] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, POB 14155-6446, Tehran, Iran
关键词
cohort study; macular thickness; OCT; ocular biometry; OPTICAL COHERENCE TOMOGRAPHY; NERVE-FIBER LAYER; RETINAL THICKNESS; BLOOD-PRESSURE; HEALTHY EYES; SERUM-LIPIDS; AXIAL LENGTH; AGE; ASSOCIATION; DIAMETER;
D O I
10.1111/ceo.14369
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
BackgroundThe aim of this study is to determine the 5-year changes in macular thickness and related factors.MethodsData were from the second (2014) and third (2019) phases of the Shahroud Eye Cohort Study. Examinations included measurement of uncorrected and best-corrected visual acuity, non-cycloplegic autorefraction, slit-lamp biomicroscopy, and funduscopy. Participants underwent Cirrus HD-OCT 4000 (Carl Zeiss Meditec, Dublin, CA). imaging.ResultsThe 5-year changes (95% confidence interval) of central and overall macular thicknesses were - 3.48 +/- 8.16 mu (-3.92, -3.03) and - 0.79 +/- 4.06 mu (-1.03, -0.54), respectively. The median and IQR of 5-year changes in the central subfield thickness were -3 and 10, although they were 0 and 5 in the overall macular thickness, respectively. Multiple regression model showed the central macular thickness (CMT) decreased with a U-shape pattern with increasing age. The 5-year changes in CMT were significantly lower in females compared to males beta = -1.55; (-2.78, -0.32) and in smokers compared to non-smokers beta = -1.92; (-3.55, -0.28). Moreover, higher body mass index beta = -0.12; (-0.22, -0.02) and CMT at baseline beta = -0.08; (-0.10, -0.06) were significantly associated with lower CMT changes. The average 5-year changes in overall macular thickness showed a non-linear decrease with age and was significantly higher in females beta = 0.93; (0.4, 1.43). These changes were directly related to the anterior chamber depth beta = 0.87; (0.10, 1.64) in the baseline.ResultsThe 5-year changes (95% confidence interval) of central and overall macular thicknesses were - 3.48 +/- 8.16 mu (-3.92, -3.03) and - 0.79 +/- 4.06 mu (-1.03, -0.54), respectively. The median and IQR of 5-year changes in the central subfield thickness were -3 and 10, although they were 0 and 5 in the overall macular thickness, respectively. Multiple regression model showed the central macular thickness (CMT) decreased with a U-shape pattern with increasing age. The 5-year changes in CMT were significantly lower in females compared to males beta = -1.55; (-2.78, -0.32) and in smokers compared to non-smokers beta = -1.92; (-3.55, -0.28). Moreover, higher body mass index beta = -0.12; (-0.22, -0.02) and CMT at baseline beta = -0.08; (-0.10, -0.06) were significantly associated with lower CMT changes. The average 5-year changes in overall macular thickness showed a non-linear decrease with age and was significantly higher in females beta = 0.93; (0.4, 1.43). These changes were directly related to the anterior chamber depth beta = 0.87; (0.10, 1.64) in the baseline.ConclusionsThe macular thickness decreased slightly after 5 years; however, this change is not clinically significant. Demographic factors such as age and sex and refractive errors were significantly related to macular thickness changes.
引用
收藏
页码:545 / 557
页数:13
相关论文
共 50 条
[21]   Five-Year Incidence and Progression of Hearing Impairment in an Older Population [J].
Mitchell, Paul ;
Gopinath, Bamini ;
Wang, Jie Jin ;
McMahon, Catherine M. ;
Schneider, Julie ;
Rochtchina, Elena ;
Leeder, Stephen R. .
EAR AND HEARING, 2011, 32 (02) :251-257
[22]   Vitamin D and Macular Thickness in the Elderly: An Optical Coherence Tomography Study [J].
Graffe, Alix ;
Beauchet, Olivier ;
Fantino, Bruno ;
Milea, Dan ;
Annweiler, Cedric .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (08) :5298-5303
[23]   Subsequent mortality experience in five-year survivors of childhood, adolescent and young adult cancer in Scotland: A population based, retrospective cohort study [J].
Brewster, David H. ;
Clark, David ;
Hopkins, Leanne ;
Bauer, Jacqui ;
Wild, Sarah H. ;
Edgar, Angela B. ;
Wallace, W. Hamish .
EUROPEAN JOURNAL OF CANCER, 2013, 49 (15) :3274-3283
[24]   Types of social participation and psychological distress in Japanese older adults: A five-year cohort study [J].
Amagasa, Shiho ;
Fukushima, Noritoshi ;
Kikuchi, Hiroyuki ;
Oka, Koichiro ;
Takamiya, Tomoko ;
Odagiri, Yuko ;
Inoue, Shigeru .
PLOS ONE, 2017, 12 (04)
[25]   Sleep Duration and Five-Year Abdominal Fat Accumulation in a Minority Cohort: The IRAS Family Study [J].
Hairston, Kristen G. ;
Bryer-Ash, Michael ;
Norris, Jill M. ;
Haffner, Steven ;
Bowden, Donald W. ;
Wagenknecht, Lynne E. .
SLEEP, 2010, 33 (03) :289-295
[26]   High Stress and Negative Health Behaviors: A Five-Year Wellness Center Member Cohort Study [J].
Clark, Matthew M. ;
Jenkins, Sarah M. ;
Hagen, Philip T. ;
Riley, Beth A. ;
Eriksen, Caleigh A. ;
Heath, Amy L. ;
Douglas, Kristin S. Vickers ;
Werneburg, Brooke L. ;
Lopez-Jimenez, Francisco ;
Sood, Amit ;
Benzo, Roberto P. ;
Olsen, Kerry D. .
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2016, 58 (09) :868-873
[27]   Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases Five-Year Japanese Cohort Study [J].
Kuwabara, Masanari ;
Niwa, Koichiro ;
Hisatome, Ichiro ;
Nakagawa, Takahiko ;
Roncal-Jimenez, Carlos A. ;
Andres-Hernando, Ana ;
Bjornstad, Petter ;
Jensen, Thomas ;
Sato, Yuka ;
Milagres, Tamara ;
Garcia, Gabriela ;
Ohno, Minoru ;
Lanaspa, Miguel A. ;
Johnson, Richard J. .
HYPERTENSION, 2017, 69 (06) :1036-+
[28]   Subfoveal choroidal thickness in a general elderly population; Tehran geriatric eye study [J].
Hashemi, Alireza ;
Nabovati, Payam ;
Mortazavi, Abolghasem ;
Hashemi, Hassan ;
Khabazkhoob, Mehdi .
BMC OPHTHALMOLOGY, 2024, 24 (01)
[29]   Natural course of the vitelliform stage in best vitelliform macular dystrophy: a five-year follow-up study [J].
Battaglia Parodi, Maurizio ;
Romano, Francesco ;
Arrigo, Alessandro ;
Di Nunzio, Carlo ;
Buzzotta, Alessio ;
Alto, Giorgio ;
Bandello, Francesco .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2020, 258 (02) :297-301
[30]   Natural course of the vitelliform stage in best vitelliform macular dystrophy: a five-year follow-up study [J].
Maurizio Battaglia Parodi ;
Francesco Romano ;
Alessandro Arrigo ;
Carlo Di Nunzio ;
Alessio Buzzotta ;
Giorgio Alto ;
Francesco Bandello .
Graefe's Archive for Clinical and Experimental Ophthalmology, 2020, 258 :297-301