Pathophysiology of myelodysplastic syndromes

被引：1

作者：

Fontenay, Michaela ^{[1
,2
]}

Boussaid, Ismael ^{[1
]}

Chapuis, Nicolas ^{[1
]}

机构：

[1] Univ Paris Cite, Hop Cochin, AP HP, Inst Cochin,lab hematol, Paris, France

[2] Univ Paris Cite, Hop Cochin, Inst Cochin, Lab Hematol Assistance,publ Hop Paris Ctr,CNRS,In, Paris, France

来源：

BULLETIN DU CANCER | 2023年 / 110卷 / 11期

关键词：

Myelodysplastic syndrome; Erythropoiesis; Mutation; Splicing; Translation; HEMATOPOIETIC STEM-CELLS; REGULATORY T-CELLS; CLONAL HEMATOPOIESIS; PROGENITOR CELLS; STRESS; MECHANISM; IDENTIFICATION; EXPANSION; ANEMIA; RNA;

D O I：

10.1016/j.bulcan.2023.02.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During aging, the onset of mutations at low frequency in hematopoietic cells or clonal hematopoiesis of indeterminate significance favors the evolution towards hemopathies such as myelodysplastic syndromes or acute leukemias, but also cardiovascular diseases and other pathologies. Acute or chronic inflammation related to age influences the clonal evolution and the immune response. Conversely, mutated hematopoietic cells create an inflammatory bone marrow environment facilitating their expansion. Various pathophysiological mechanisms depending on the type of mutation produce the diversity of phenotypes. Identifying factors affecting clonal selection is mandatory to improve patient care.

引用

页码：1097 / 1105

页数：9

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