New insights in application of mesenchymal stem cells therapy in tumor microenvironment: pros and cons

被引：20

作者：

Afkhami, Hamed ^{[1
,2
,3
]}

Mahmoudvand, Golnaz ^{[4
]}

Fakouri, Arshia ^{[4
]}

Shadab, Alireza ^{[5
,6
]}

Mahjoor, Mohamad ^{[2
,7
]}

Movahhed, Tahereh Komeili ^{[2
]}

机构：

[1] Semnan Univ Med Sci, Nervous Syst Stem Cells Res Ctr, Semnan, Iran

[2] Qom Univ Med Sci, Cellular & Mol Res Ctr, Qom, Iran

[3] Shahed Univ, Fac Med, Dept Med Microbiol, Tehran, Iran

[4] Lorestan Univ Med Sci, Student Res Comm, USERN Off, Khorramabad, Iran

[5] Semnan Univ Med Sci, Sch Med, Dept Immunol, Semnan, Iran

[6] Iran Univ Med Sci, Deputy Hlth, Tehran, Iran

[7] Iran Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

mesenchymal stem cell (MSC); cell-and tissue-based therapy; stem cell transplantation; neoplasm; tumor microenvironment (TME); APOPTOSIS-INDUCING LIGAND; MOUSE XENOGRAFT MODEL; STROMAL CELLS; T-CELL; EXTRACELLULAR VESICLES; GENE-THERAPY; CANCER-CELLS; IN-VITRO; B-CELLS; GROWTH;

D O I：

10.3389/fcell.2023.1255697

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multipotent mesenchymal stem cells (MSCs) are widely accepted as a useful tool for cell-based therapy of various diseases including malignancies. The therapeutic effects of MSCs are mainly attributed to their immunomodulatory and immunosuppressive properties. Despite the promising outcomes of MSCs in cancer therapy, a growing body of evidence implies that MSCs also show tumorigenic properties in the tumor microenvironment (TME), which might lead to tumor induction and progression. Owing to the broad-spectrum applications of MSCs, this challenge needs to be tackled so that they can be safely utilized in clinical practice. Herein, we review the diverse activities of MSCs in TME and highlight the potential methods to convert their protumorigenic characteristics into onco-suppressive effects.

引用

页数：13

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