Resting-State EEG Microstates and Power Spectrum in Borderline Personality Disorder: A High-Density EEG Study

被引:2
作者
Deiber, Marie-Pierre [1 ,2 ]
Piguet, Camille [2 ,3 ]
Berchio, Cristina [4 ]
Michel, Christoph M. [5 ,6 ]
Perroud, Nader [2 ,7 ]
Ros, Tomas [2 ,6 ,8 ]
机构
[1] Univ Hosp Geneva, Dept Psychiat, Geriatr Psychiat Div, Chemin Petit Bel Air 2, CH-1226 Geneva, Switzerland
[2] Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland
[3] Univ Hosp Geneva, Dept Pediat, Geneva, Switzerland
[4] Univ Geneva, Dept Pediat, Geneva, Switzerland
[5] Univ Geneva, Dept Fundamental Neurosci, Funct Brain Mapping Lab, Geneva, Switzerland
[6] Ctr Biomed Imaging, Lausanne, Switzerland
[7] Univ Hosp Geneva, Dept Psychiat, Div Psychiat Specialties, Geneva, Switzerland
[8] Univ Geneva, Dept Neurosci, Geneva, Switzerland
基金
瑞士国家科学基金会;
关键词
Borderline personality disorder (BPD); EEG; Resting-state; Microstates (MS); Alpha rhythm; CINGULO-OPERCULAR NETWORK; SCALE; ALPHA; RELIABILITY; DYNAMICS; MODEL;
D O I
10.1007/s10548-023-01005-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Borderline personality disorder (BPD) is a debilitating psychiatric condition characterized by emotional dysregulation, unstable sense of self, and impulsive, potentially self-harming behavior. In order to provide new neurophysiological insights on BPD, we complemented resting-state EEG frequency spectrum analysis with EEG microstates (MS) analysis to capture the spatiotemporal dynamics of large-scale neural networks. High-density EEG was recorded at rest in 16 BPD patients and 16 age-matched neurotypical controls. The relative power spectrum and broadband MS spatiotemporal parameters were compared between groups and their inter-correlations were examined. Compared to controls, BPD patients showed similar global spectral power, but exploratory univariate analyses on single channels indicated reduced relative alpha power and enhanced relative delta power at parietal electrodes. In terms of EEG MS, BPD patients displayed similar MS topographies as controls, indicating comparable neural generators. However, the MS temporal dynamics were significantly altered in BPD patients, who demonstrated opposite prevalence of MS C (lower than controls) and MS E (higher than controls). Interestingly, MS C prevalence correlated positively with global alpha power and negatively with global delta power, while MS E did not correlate with any measures of spectral power. Taken together, these observations suggest that BPD patients exhibit a state of cortical hyperactivation, represented by decreased posterior alpha power, together with an elevated presence of MS E, consistent with symptoms of elevated arousal and/or vigilance. This is the first study to investigate resting-state MS patterns in BPD, with findings of elevated MS E and the suggestion of reduced posterior alpha power indicating a disorder-specific neurophysiological signature previously unreported in a psychiatric population.
引用
收藏
页码:397 / 409
页数:13
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