Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer′s Disease Study (LEADS)

被引：31

作者：

Cho, Hanna ^{[2
,3
,4
]}

Mundada, Nidhi S. ^{[2
]}

Apostolova, Liana G. ^{[5
,6
,7
]}

Carrillo, Maria C. ^{[8
]}

Shankar, Ranjani ^{[2
]}

Amuiri, Alinda N. ^{[2
]}

Zeltzer, Ehud ^{[2
]}

Windon, Charles C. ^{[2
]}

Soleimani-Meigooni, David N. ^{[2
]}

Tanner, Jeremy A. ^{[2
]}

Heath, Courtney Lawhn ^{[9
]}

Lesman-Segev, Orit H. ^{[2
,10
]}

Aisen, Paul ^{[11
]}

Eloyan, Ani ^{[12
]}

Lee, Hye Sun ^{[13
]}

Hammers, Dustin B. ^{[5
]}

Kirby, Kala ^{[5
]}

Dage, Jeffrey L. ^{[5
]}

Fagan, Anne ^{[14
]}

Foroud, Tatiana ^{[7
]}

Grinberg, Lea T. ^{[2
,15
]}

Jack, Clifford R. ^{[16
]}

Kramer, Joel ^{[2
]}

Kukull, Walter A. ^{[17
]}

Murray, Melissa E. ^{[18
]}

Nudelman, Kelly ^{[7
]}

Toga, Arthur ^{[19
]}

Vemuri, Prashanthi ^{[16
]}

Atri, Alireza ^{[20
]}

Day, Gregory S. ^{[21
]}

Duara, Ranjan ^{[22
]}

Graff-Radford, Neill R. ^{[21
]}

Honig, Lawrence S. ^{[23
]}

Jones, David T. ^{[16
,24
]}

Masdeu, Joseph ^{[25
]}

Mendez, Mario ^{[26
]}

Musiek, Erik ^{[14
]}

Onyike, Chiadi U. ^{[27
]}

Riddle, Meghan ^{[28
]}

Rogalski, Emily J. ^{[29
]}

Salloway, Stephen ^{[28
]}

Sha, Sharon ^{[30
]}

Turner, Raymond Scott ^{[31
,32
]}

Wingo, Thomas S.

Wolk, David A. ^{[33
]}

Koeppe, Robert ^{[34
]}

Iaccarino, Leonardo ^{[2
]}

Dickerson, Bradford C. ^{[35
,36
]}

La Joie, Renaud ^{[2
]}

Rabinovici, Gil D. ^{[1
,2
,9
]}

机构：

[1] Univ Calif San Francisco, San Francisco UCSF, Memory & Aging Ctr, MC 1207, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA

[3] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Neurol, Seoul, South Korea

[4] Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA USA

[5] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN USA

[6] Indiana Univ Sch Med, Ctr Neuroimaging, Dept Radiol & Imaging Sci, Indianapolis, IN 46204 USA

[7] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN USA

[8] Alzheimers Assoc, Med & Sci Relat Div, Chicago, IL USA

[9] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[10] Sheba Med Ctr, Dept Diagnost Imaging, Tel Hashomer, Israel

[11] Univ Southern Calif, Alzheimers Therapeut Res Inst, San Diego, CA USA

[12] Brown Univ, Ctr Stat Sci, Dept Biostat, Providence, RI 02912 USA

[13] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul 120752, South Korea

[14] Washington Univ St Louis, Dept Neurol, St Louis, MO USA

[15] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[16] Mayo Clin, Dept Radiol, Rochester, MN USA

[17] Univ Washington, Dept Epidemiol, Seattle, WA USA

[18] Mayo Clin, Dept Neurosci, Jacksonville, FL USA

[19] Univ Southern Calif, USC Stevens Neuroimaging & Informat Inst, Keck Sch Med USC, Lab Neuro Imaging, Los Angeles, CA 90007 USA

[20] Banner Sun Hlth Res Inst, Sun City, AZ USA

[21] Mayo Clin, Dept Neurol, Jacksonville, FL USA

[22] Mt Sinai Med Ctr, Wien Ctr Alzheimers Dis & Memory Disorders, Miami, FL USA

[23] Columbia Univ, Irving Med Ctr, Dept Neurol, New York, NY USA

[24] Mayo Clin, Dept Neurol, Rochester, MN USA

[25] Houston Methodist and Weill Cornell Med, Nantz Natl Alzheimer Ctr, Houston, TX USA

[26] David Geffen Sch Med UCLA, Dept Neurol, Los Angeles, CA USA

[27] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD USA

[28] Brown Univ, Alpert Med Sch, Dept Neurol, Providence, RI 02912 USA

[29] Northwestern Univ, Mesualm Ctr Cognit Neurol & Alzheimers Dis, Feinberg Sch Med, Chicago, IL USA

[30] Stanford Univ, Dept Neurol & Neurol Sci, Palo Alto, CA USA

[31] Georgetown Univ, Dept Neurol, Washington, DC USA

[32] Emory Univ, Dept Neurol & Human Genet, Dept Human Genet, Sch Med, Atlanta, GA USA

[33] Univ Penn, Perelman Sch Med, Dept Neurol, Philadelphia, PA USA

[34] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48105 USA

[35] Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[36] Harvard Med Sch, Boston, MA USA

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷

关键词：

Alzheimer ' s disease; amyloid-PET; atypical AD; centiloids; early-onset; EOAD; LEADS; sex differences; tau-PET; POSITRON-EMISSION-TOMOGRAPHY; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; COGNITIVE IMPAIRMENT; DEMENTIA; RECOMMENDATIONS; BIOMARKERS; RETENTION; VARIANT;

D O I：

10.1002/alz.13453

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: We aimed to describe baseline amyloid-beta (A ss) and tau-positron emission tomograrphy (PET) from Longitudinal Early-onset Alzheimer ' s Disease Study (LEADS), a prospective multi-site observational study of sporadic early-onset Alzheimer ' s disease (EOAD). METHODS: We analyzed baseline [18F]Florbetaben (A ss) and [18F]Flortaucipir (tau)PET from cognitively impaired participants with a clinical diagnosis of mild cognitive impairment (MCI) or AD dementia aged < 65 years. Florbetaben scans were used to distinguish cognitively impaired participants with EOAD (A ss+) from EOnonAD (A ss-) based on the combination of visual read by expert reader and image quantification. RESULTS: 243/321 (75.7%) of participants were assigned to the EOAD group based on amyloid-PET; 231 (95.1%) of them were tau-PET positive (A+T+). Tau-PET signal was elevated across cortical regions with a parietal-predominant pattern, and higher burden was observed in younger and female EOAD participants. DISCUSSION: LEADS data emphasizes the importance of biomarkers to enhance diagnostic accuracy in EOAD. The advanced tau-PET binding at baseline might have implications for therapeutic strategies in patients with EOAD.

引用

页码：S98 / S114

页数：17

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