Pomegranate (Punica granatum L.) peel extract ameliorates metabolic syndrome risk factors in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trial

被引：19

作者：

Barghchi, Hanieh ^{[1
,2
]}

Milkarizi, Narges ^{[3
]}

Belyani, Saba ^{[4
]}

Norouzian Ostad, Andisheh ^{[1
]}

Askari, Vahid Reza ^{[5
,6
]}

Rajabzadeh, Farnood ^{[7
]}

Goshayeshi, Ladan ^{[8
,9
]}

Ghelichi Kheyrabadi, Seyede Yegane ^{[1
]}

Razavidarmian, Maryam ^{[10
]}

Dehnavi, Zahra ^{[1
,2
]}

Sobhani, Seyyed Reza ^{[1
]}

Nematy, Mohsen ^{[1
,3
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran

[2] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran

[3] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Dept Nutr, Mashhad, Iran

[4] North Khorasan Univ Med Sci, Student Res Comm, Bojnourd, Iran

[5] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran

[6] Mashhad Univ Med Sci, Neurogenic Inflammat Res Ctr, Mashhad, Iran

[7] Islamic Azad Univ, Dept Radiol, Mashhad Med Sci Branch, Mashhad, Iran

[8] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran

[9] Mashhad Univ Med Sci, Gastroenterol & Hepatol Res Ctr, Mashhad, Iran

[10] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Iran

来源：

NUTRITION JOURNAL | 2023年 / 22卷 / 01期

关键词：

Pomegranate Peel; Metabolic syndrome; Fatty liver; Dyslipidemia; Hypertension; OXIDATIVE STRESS; OBESE WOMEN; SUPPLEMENTATION; DIET; INFLAMMATION; POLYPHENOLS; ACCUMULATION; CELLS; NAFLD;

D O I：

10.1186/s12937-023-00869-2

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk factors.MethodsIn phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. Then, in phase two, NAFLD patients received 1500 mg of placebo (n = 37) or pomegranate peel capsules (n = 39) with a 500-kcal deficit diet for 8 weeks. Gastrointestinal intolerance, dietary intake, lipid and glycemic profiles, systolic and diastolic blood pressure, body composition, insulin resistance indexes, and elastography-evaluated NAFLD changes were followed.ResultsThe mean age of participants was 43.1 & PLUSMN; 8.6 years (51.3% female). Following the intervention, the mean body weight (mean changes: -5.10 & PLUSMN; 2.30 kg), waist circumference (-7.57 & PLUSMN; 2.97 cm), body mass index (-1.82 & PLUSMN; 0.85 kg/m(2)), body fat index (-1.49 & PLUSMN; 0.86), and trunk fat (- 3.93 & PLUSMN; 3.07%), systolic (-0.63 & PLUSMN; 0.29 cmHg) and diastolic (-0.39 & PLUSMN; 0.19 cmHg) blood pressure, total cholesterol (-10.51 & PLUSMN; 0.77 mg/dl), triglyceride (-16.02 & PLUSMN; 1.7 mg/dl), low-density lipoprotein cholesterol (-9.33 & PLUSMN; 6.66 mg/dl; all P < 0.001), fat free mass (- 0.92 & PLUSMN; 0.90 kg; P < 0.003), and fasting blood sugar (-5.28 & PLUSMN; 1.36 mg/dl; P = 0.02) decreased significantly in PP in contrast to the placebo group in the raw model and when adjusted for confounders. Also, high-density lipoprotein cholesterol (5.10 & PLUSMN; 0.36 mg/dl), liver steatosis and stiffness (- 0.30 & PLUSMN; 0.17 and - 0.72 & PLUSMN; 0.35 kPa, respectively, all P < 0.001) improved in the PP group. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw and even adjusted models.ConclusionIn conclusion, 1500 mg pomegranate peel extract along with a weight-loss diet improved metabolic syndrome risk factors and reduced hepatic steatosis in patients with NAFLD after 8 weeks.

引用

页数：17

共 84 条

[1] White Bean seeds and Pomegranate peel and fruit seeds as hypercholesterolemic and hypolipidemic agents in albino rats [J].