Multidimensional biomarkers for multiple system atrophy: an update and future directions

被引：8
作者：
Wan, Linlin [1 ,3 ,4 ,5 ,8 ]
Zhu, Sudan [1 ]
Chen, Zhao [1 ,3 ,4 ,6 ]
Qiu, Rong [7 ]
Tang, Beisha [1 ,3 ,4 ,6 ]
Jiang, Hong [1 ,2 ,3 ,4 ,6 ,8 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China
[2] Cent South Univ, Xiangya Hosp 3, Dept Neurol, Changsha 410013, Peoples R China
[3] Cent South Univ, Key Lab Hunan Prov Neurodegenerat Disorders, Changsha 410008, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Dept Radiol, Changsha 410008, Peoples R China
[6] Hunan Int Sci & Technol Cooperat Base Neurodegener, Changsha 410008, Peoples R China
[7] Cent South Univ, Sch Comp Sci & Engn, Changsha 410083, Peoples R China
[8] Cent South Univ, Natl Int Collaborat Res Ctr Med Metabol, Changsha 410008, Peoples R China
来源：
TRANSLATIONAL NEURODEGENERATION | 2023年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Multiple system atrophy; Biomarker; Fluid; Tissue; Gut microbiota; Imaging; ALPHA-SYNUCLEIN LEVELS; NEUROFILAMENT LIGHT-CHAIN; PROGRESSIVE SUPRANUCLEAR PALSY; CEREBROSPINAL-FLUID BIOMARKERS; MYELIN BASIC-PROTEIN; PARKINSONS-DISEASE; DIFFERENTIAL-DIAGNOSIS; OLFACTORY MUCOSA; POTENTIAL BIOMARKER; COENZYME-Q10; LEVELS;
D O I：
10.1186/s40035-023-00370-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Multiple system atrophy (MSA) is a fatal progressive neurodegenerative disease. Biomarkers are urgently required for MSA to improve the diagnostic and prognostic accuracy in clinic and facilitate the development and monitoring of disease-modifying therapies. In recent years, significant research efforts have been made in exploring multidimensional biomarkers for MSA. However, currently few biomarkers are available in clinic. In this review, we systematically summarize the latest advances in multidimensional biomarkers for MSA, including biomarkers in fluids, tissues and gut microbiota as well as imaging biomarkers. Future directions for exploration of novel biomarkers and promotion of implementation in clinic are also discussed.
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页数：17
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