Clinical parameters correlated with the psoas muscle index in Japanese individuals with type 2 diabetes mellitus

被引：0

作者：

Asano-Hayami, Emi ^{[1
]}

Morishita, Yoshiaki ^{[1
]}

Hayami, Tomohide ^{[1
]}

Shibata, Yuka ^{[1
,2
]}

Kiyose, Toshiki ^{[1
]}

Sasajima, Sachiko ^{[1
]}

Hayashi, Yusuke ^{[1
]}

Motegi, Mikio ^{[1
]}

Kato, Makoto ^{[1
]}

Asano, Saeko ^{[1
]}

Nakai-Shimoda, Hiromi ^{[1
]}

Yamada, Yuichiro ^{[1
]}

Miura-Yura, Emiri ^{[1
]}

Himeno, Tatsuhito ^{[1
,3
]}

Kondo, Masaki ^{[1
]}

Tsunekawa, Shin ^{[1
]}

Kato, Yoshiro ^{[1
]}

Nakamura, Jiro ^{[1
,3
]}

Kamiya, Hideki ^{[1
]}

机构：

[1] Aichi Med Univ, Dept Internal Med, Div Diabet, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[2] Aichi Med Univ Hosp, Dept Clin Lab, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

[3] Aichi Med Univ, Dept Innovat Diabet Therapy, Sch Med, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

来源：

DIABETOLOGY INTERNATIONAL | 2023年 / 14卷 / 01期

关键词：

Type; 2; diabetes; Psoas muscle index; Muscle mass loss; Thyroid function; OLDER-ADULTS; INSULIN-SECRETION; NONOBESE PATIENTS; MASS; SARCOPENIA; RECEPTOR; DISEASE; ATROPHY; RISK; TRIIODOTHYRONINE;

D O I：

10.1007/s13340-022-00602-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Muscle atrophy is a diabetic complication, which results in a deterioration in glycemic control in type 2 diabetes mellitus (T2DM) individuals. The psoas muscle mass index (PMI) is a reliable indicator for estimating whole-body muscle mass. We aimed to examine the relationship between clinical parameters and the PMI to clarify the mechanism underlying muscle atrophy in diabetes. Methods This retrospective, cross-sectional study examined 51 patients (31 men and 20 women) with T2DM and a mean HbA1c value of 9.9 +/- 1.7%. These patients were admitted to Aichi Medical University Hospital and underwent abdominal computed tomography imaging from July 2020 to April 2021. Multiple clinical parameters were assessed with the PMI. Results In a multiple regression analysis adjusted for age and sex, the PMI was correlated with body weight, body mass index, serum concentrations of corrected calcium, aspartate aminotransferase, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone (TSH), urinary C-peptide concentrations, the free triiodothyronine/free thyroxine (FT3/FT4) ratio, and the young adult mean score at the femur neck. Receiver operating characteristic curves were created using TSH concentrations and the FT3/FT4 ratio for diagnosing a low PMI. The area under the curve was 0.593 and 0.699, respectively. The cut-off value with maximum accuracy for TSH concentrations was 1.491 mu IU/mL, sensitivity was 56.1%, and specificity was 80.0%. Corresponding values for the FT3/FT4 ratio were 1.723, 78.0, and 66.7%, respectively. Conclusion TSH concentrations and the FT3/FT4 ratio are correlated with the PMI, and their thresholds may help prevent muscle mass loss in Japanese individuals with T2DM.

引用

页码：76 / 85

页数：10

共 54 条

[1] Muscular atrophy in diabetic neuropathy: a stereological magnetic resonance imaging study [J].

Andersen, H ;

Gadeberg, PC ;

Brock, B ;

Jakobsen, J .

DIABETOLOGIA, 1997, 40 (09) :1062-1069

[2] Atrophy of foot muscles [J].

Andersen, H ;

Gjerstad, MD ;

Jakobsen, J .

DIABETES CARE, 2004, 27 (10) :2382-2385

[3]

[Anonymous], 2015, Nat Rev Dis Primers, V1, P15039, DOI [10.1038/nrdp.2015.39, 10.1038/nrdp.2015.39]

[4] The clinical significance of subclinical thyroid dysfunction [J].

Biondi, Bernadette ;

Cooper, David S. .

ENDOCRINE REVIEWS, 2008, 29 (01) :76-131

[5] Quantification of cells expressing the thyrotropin receptor in extraocular muscles in thyroid associated orbitopathy [J].

Boschi, A ;

Daumerie, C ;

Spiritus, M ;

Beguin, C ;

Senou, M ;

Yuksel, D ;

Duplicy, M ;

Costagliola, S ;

Ludgate, M ;

Many, MC .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2005, 89 (06) :724-729

[6] Biochemical markers of muscular damage [J].

Brancaccio, Paola ;

Lippi, Giuseppe ;

Maffulli, Nicola .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2010, 48 (06) :757-767

[7] The impact of overt and subclinical hyperthyroidism on skeletal muscle [J].

Brennan, Michael D. ;

Powell, Claudia ;

Kaufman, Kenton R. ;

Sun, Pi Chang ;

Bahn, Rebecca S. ;

Nair, K. Sreekumaran .

THYROID, 2006, 16 (04) :375-380

[8] Control of glucose uptake and release by the liver in vivo [J].

Cherrington, AD .

DIABETES, 1999, 48 (05) :1198-1214

[9]

Chung Y H, 1986, Korean J Intern Med, V1, P172

[10] De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone [J].

Citterio, Cintia E. ;

Veluswanny, Balaji ;

Morgan, Sarah J. ;

Galton, Valerie A. ;

Banga, J. Paul ;

Atkins, Stephen ;

Morishita, Yoshiaki ;

Neumann, Susanne ;

Latif, Rauf ;

Gershengorn, Marvin C. ;

Smith, Terry J. ;

Arvan, Peter .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (37) :15434-15444

← 1 2 3 4 5 6 →