Pediatric patients suffering traumatic brain injuries may require a decompressive craniectomy to accommodate brain swelling by removing a portion of the skull. Once the brain swelling subsides, the preserved calvarial bone flap is ideally replaced as an autograft during a cranioplasty to restore protection of the brain, as it can reintegrate and grow with the patient during immature skeletal development. However, pediatric patients exhibit a high prevalence of calvarial bone flap resorption post-cranioplasty, causing functional and cosmetic morbidity. This review examines possible solutions for mitigating pediatric calvarial bone flap resorption by delineating methods of stimulating mechanosensitive cell populations with mechanical forces. Mechanotransduction plays a critical role in three main cell types involved with calvarial bone repair, including mesenchymal stem cells, osteoblasts, and dural cells, through mechanisms that could be exploited to promote osteogenesis. In particular, physiologically relevant mechanical forces, including substrate deformation, external forces, and ultrasound, can be used as tools to stimulate bone repair in both in vitro and in vivo systems. Ultimately, combating pediatric calvarial flap resorption may require a combinatorial approach using both cell therapy and bioengineering strategies.
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UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Al Hosni, Rawiya
Bozec, Laurent
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Univ Toronto, Fac Dent, 12 Edward St, Toronto, ON M5G 1G6, CanadaUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Bozec, Laurent
Roberts, Scott J.
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UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Royal Vet Coll, Dept Comparat Biomed Sci, 4 Royal Coll St, London NW1 0TU, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Roberts, Scott J.
Cheema, Umber
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UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
机构:
Sir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Bhaskar, Ivan Paul
Li Yusheng
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Univ Western Australia, Orthopaed Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Li Yusheng
Zheng, Minghao
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Univ Western Australia, Orthopaed Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Zheng, Minghao
Lee, Gabriel Yin Foo
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Sir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Univ Western Australia, Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
机构:
UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Al Hosni, Rawiya
Bozec, Laurent
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Fac Dent, 12 Edward St, Toronto, ON M5G 1G6, CanadaUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Bozec, Laurent
Roberts, Scott J.
论文数: 0引用数: 0
h-index: 0
机构:
UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Royal Vet Coll, Dept Comparat Biomed Sci, 4 Royal Coll St, London NW1 0TU, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
Roberts, Scott J.
Cheema, Umber
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h-index: 0
机构:
UCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, EnglandUCL, UCL Ctr 3D Models Hlth & Dis, Div Surg & Intervent Sci, 43-45 Foley St, London W1W 7TY, England
机构:
Sir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Bhaskar, Ivan Paul
Li Yusheng
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Orthopaed Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Li Yusheng
Zheng, Minghao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Western Australia, Orthopaed Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Zheng, Minghao
Lee, Gabriel Yin Foo
论文数: 0引用数: 0
h-index: 0
机构:
Sir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia
Univ Western Australia, Sch Surg, Nedlands, WA 6009, AustraliaSir Charles Gairdner Hosp, Dept Neurosurg, Nedlands, WA 6009, Australia