The potential role of mechanotransduction in the management of pediatric calvarial bone flap repair

被引:0
作者
Anderson, Hanna [1 ,2 ]
Hersh, David S. [3 ,4 ]
Khan, Yusuf [1 ,2 ,5 ]
机构
[1] Univ Connecticut, Biomed Engn, Storrs, CT USA
[2] UConn Hlth, Cato T Laurencin Inst Regenerat Engn, Farmington, CT USA
[3] UConn Sch Med, Dept Surg, Farmington, CT USA
[4] Connecticut Childrens Med Ctr, Div Neurosurg, Hartford, CT USA
[5] UConn Hlth, Orthopaed Surg, Farmington, CT 06030 USA
基金
美国国家卫生研究院;
关键词
bone resorption; dural cells; mechanotransduction; osteoblasts; pediatric; ultrasound; INTENSITY PULSED ULTRASOUND; TRAUMATIC BRAIN-INJURY; STEM-CELL BEHAVIOR; DURA-MATER; DECOMPRESSIVE CRANIECTOMY; SUBSTRATE STIFFNESS; EXTRACELLULAR-MATRIX; FOCAL ADHESIONS; DIFFERENTIATION; CRANIOPLASTY;
D O I
10.1002/bit.28534
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Pediatric patients suffering traumatic brain injuries may require a decompressive craniectomy to accommodate brain swelling by removing a portion of the skull. Once the brain swelling subsides, the preserved calvarial bone flap is ideally replaced as an autograft during a cranioplasty to restore protection of the brain, as it can reintegrate and grow with the patient during immature skeletal development. However, pediatric patients exhibit a high prevalence of calvarial bone flap resorption post-cranioplasty, causing functional and cosmetic morbidity. This review examines possible solutions for mitigating pediatric calvarial bone flap resorption by delineating methods of stimulating mechanosensitive cell populations with mechanical forces. Mechanotransduction plays a critical role in three main cell types involved with calvarial bone repair, including mesenchymal stem cells, osteoblasts, and dural cells, through mechanisms that could be exploited to promote osteogenesis. In particular, physiologically relevant mechanical forces, including substrate deformation, external forces, and ultrasound, can be used as tools to stimulate bone repair in both in vitro and in vivo systems. Ultimately, combating pediatric calvarial flap resorption may require a combinatorial approach using both cell therapy and bioengineering strategies.
引用
收藏
页码:39 / 52
页数:14
相关论文
共 99 条
  • [1] Controlling stem cell behavior with decellularized extracellular matrix scaffolds
    Agmon, Gillie
    Christman, Karen L.
    [J]. CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, 2016, 20 (04) : 193 - 201
  • [2] Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension
    Al Hosni, Rawiya
    Bozec, Laurent
    Roberts, Scott J.
    Cheema, Umber
    [J]. ISCIENCE, 2022, 25 (04)
  • [3] Current advances in regulation of bone homeostasis
    Al-Bari, Abdul Alim
    Al Mamun, Abdullah
    [J]. FASEB BIOADVANCES, 2020, 2 (11) : 668 - 679
  • [4] Ultrasound-derived mechanical stimulation of cell-laden collagen hydrogels for bone repair
    Assanah, Fayekah
    Grassie, Kevin
    Anderson, Hanna
    Xin, Xiaonan
    Rowe, David
    Khan, Yusuf
    [J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2023, 111 (08) : 1200 - 1215
  • [5] Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus
    Azuma, Y
    Ito, M
    Harada, Y
    Takagi, H
    Ohta, T
    Jingushi, S
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (04) : 671 - 680
  • [6] Extracellular matrix as a biological scaffold material: Structure and function
    Badylak, Stephen F.
    Freytes, Donald O.
    Gilbert, Thomas W.
    [J]. ACTA BIOMATERIALIA, 2009, 5 (01) : 1 - 13
  • [7] Bauer TW, 2000, CLIN ORTHOP RELAT R, P10
  • [8] Split rib cranioplasty for aplasia cutis congenita and traumatic skull defects: More than 30 years of follow-up
    Beekmans, Sander J. A.
    Don Griot, J. Peter W.
    Mulder, J. Wiebe
    [J]. JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (03) : 594 - 597
  • [9] Autogenous skull flaps stored frozen for more than 6 months: do they remain viable?
    Bhaskar, Ivan Paul
    Li Yusheng
    Zheng, Minghao
    Lee, Gabriel Yin Foo
    [J]. JOURNAL OF CLINICAL NEUROSCIENCE, 2011, 18 (12) : 1690 - 1693
  • [10] Collagen abundance in mechanically stimulated osteoblast cultures using near infrared microscopy
    Boada-Lopez, Jairo
    DeJesus-Maldonado, Idaris
    Jerez, Jackeline
    Romanach, Rodolfo
    Diffoot-Carlo, Nanette
    Sundaram, Paul
    [J]. JOURNAL OF BIOMECHANICS, 2013, 46 (14) : 2442 - 2450