Zn@CS: An Efficient Cu-Free Catalyst System for Direct Azide-Alkyne Cycloadditions and Multicomponent Synthesis of 4-Aryl-NH-1,2,3-triazoles in H2O and DES

被引：6

作者：

Sultana, Jasmin ^{[1
]}

Garg, Anirban ^{[1
]}

Kulshrestha, Akshay ^{[2
]}

Rohman, Shahnaz S. ^{[3
]}

Dutta, Bidyutjyoti ^{[1
]}

Singh, Kuldeep ^{[2
]}

Kumar, Arvind ^{[2
]}

Guha, Ankur K. ^{[3
]}

Sarma, Diganta ^{[1
]}

机构：

[1] Dibrugarh Univ, Dept Chem, Dibrugarh 786004, Assam, India

[2] Cent Salt & Marine Chem Res Inst, Salt & Marine Chem Div, CSIR, Bhavnagar 364002, India

[3] Cotton Univ, Dept Chem, Gauhati 781001, Assam, India

来源：

CATALYSIS LETTERS | 2023年 / 153卷 / 11期

关键词：

ZnAAC; Biopolymeric support; DES; Heterogeneous; NH-1,2,3-triazoles; ONE-POT SYNTHESIS; CLICK CHEMISTRY; TERMINAL ALKYNES; SODIUM-AZIDE; CHITOSAN; ALDEHYDES; NITROALKANES; CONDENSATION; TRIAZOLES; LIGATION;

D O I：

10.1007/s10562-022-04248-0

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A highly efficient recoverable and reusable heterogeneous Zn-catalyst, chitosan supported ZnSO4. 7H(2)O (designated as Zn@CS) is synthesized via a simple synthetic route. Low catalyst loading, need of aqueous reaction media and sharp reduction of time requirement in comparison to the previously reported methodologies are some special features of the established Zn catalyzed direct azide-alkyne cycloaddition reaction. Zn@CS-catalyst is also suitable for multicomponent synthesis of 4-aryl-NH-1,2,3-triazoles from different derivatives of benzaldehyde. An inexpensive and environmentally benign deep eutectic solvent (DES), ChCl:PEG-400:Glycerol as a suitable reaction media accelerates these reactions leading to excellent yields of NH-triazoles. Based on literature report a plausible mechanism has been suggested for ZnAAC reaction.

引用

页码：3516 / 3526

页数：11

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