Bone health in inflammatory bowel disease

被引：4
作者：
Wei, Hao [1 ,2 ]
Zhao, Yihan [3 ,4 ]
Xiang, Lisha [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, Thorac Oncol Ward, Canc Ctr, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Dept Cardiol, Chengdu, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu, Peoples R China
来源：
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2023年
关键词：
Fracture; inflammatory bowel disease; osteoporosis; osteopenia; pediatric; EXCLUSIVE ENTERAL NUTRITION; QUALITY-OF-LIFE; GROWTH-FACTOR-I; PEDIATRIC CROHNS-DISEASE; POPULATION-BASED COHORT; VITAMIN-D DEFICIENCY; TNF-ALPHA THERAPY; MINERAL DENSITY; ULCERATIVE-COLITIS; EXTRAINTESTINAL MANIFESTATIONS;
D O I：
10.1080/17474124.2023.2248874
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
IntroductionInflammatory bowel disease (IBD) is a chronic disease characterized by the presence of systemic inflammation, manifesting not only as gastrointestinal symptoms but also as extraintestinal bone complications, including osteopenia and osteoporosis. However, the association between IBD and osteoporosis is complex, and the presence of multifactorial participants in the development of osteoporosis is increasingly recognized. Unlike in adults, delayed puberty and growth hormone/insulin-like growth factor-1 axis abnormalities are essential risk factors for osteoporosis in pediatric patients with IBD.Areas coveredThis article reviews the potential pathophysiological mechanisms contributing to osteoporosis in adult and pediatric patients with IBD and provides evidence for effective prevention and treatment, focusing on pediatric patients with IBD. A search was performed from PubMed and Web of Science inception to February 2023 to identify articles on IBD, osteoporosis, pediatric, and fracture risk.Expert opinionA comprehensive treatment pattern based on individualized principles can be used to manage pediatric IBD-related osteoporosis.
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收藏
页码：921 / 935
页数：15
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