Standardized Definitions for Evaluation of Acute Decompensated Heart Failure Therapies HF-ARC Expert Panel Paper

被引：15

作者：

Lala, Anuradha ^{[1
,2
]}

Hamo, Carine E. ^{[3
]}

Bozkurt, Biykem ^{[4
,5
]}

Fiuzat, Mona ^{[6
]}

Blumer, Vanessa ^{[7
]}

Bukhoff, Daniel ^{[8
,9
]}

Butler, Javed ^{[10
,11
]}

Costanzo, Maria Rosa ^{[12
]}

Felker, G. Michael ^{[6
]}

Filippatos, Gerasimos ^{[13
]}

Konstam, Marvin A. ^{[14
]}

McMurray, John J. V. ^{[15
]}

Mentz, Robert J. ^{[6
]}

Metra, Marco ^{[16
,17
]}

Psotka, Mitchell A. ^{[18
]}

Solomon, Scott D. ^{[19
]}

Teerlink, John ^{[20
,21
]}

Abraham, William T. ^{[22
]}

O'Conno, Christopher M. ^{[6
,18
]}

机构：

[1] Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA

[2] Dept Populat Hlth Sci & Policy, New York, NY USA

[3] NYU, New York Univ Langone Hlth, Sch Med, Leon H Charney Div Cardiol, New York, NY USA

[4] Baylor Coll Med, Winters Ctr Heart Failure, Cardiol, Houston, TX USA

[5] Michael E DeBakey VA Med Ctr, Houston, TX USA

[6] Duke Univ, Sch Med, Div Cardiol, Durham, NC USA

[7] Cleveland Clin, Heart & Vasc Inst, Kaufman Ctr Heart Failure, Dept Cardiovasc Med, Cleveland, OH USA

[8] Tufts Med Ctr, Div Cardiol, Boston, MA USA

[9] Cardiovasc Res Fdn, New York, NY USA

[10] Baylor Scott & White Res Inst, Dallas, TX USA

[11] Univ Mississippi, Med Ctr, Jackson, MS USA

[12] Advocate Heart Inst, Naperville, IL USA

[13] Univ Cyprus, Shakolas Educ Ctr Clin Med, Med Sch, Nicosia, Cyprus

[14] Tufts Med Ctr, Cardiovasc Ctr, Boston, MA USA

[15] Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Sch Cardiovasc & Metab Hlth, Glasgow, Lanark, Scotland

[16] Univ Brescia, Civil Hosp, Cardiothorac Dept, Cardiol, Brescia, Italy

[17] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy

[18] Inova Heart & Vasc Inst, Falls Church, VA USA

[19] Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA

[20] San Francisco VA Med Ctr, Sect Cardiol, San Francisco, CA USA

[21] Univ Calif San Francisco, Sch Med, San Francisco, CA USA

[22] Ohio State Univ, Div Cardiovasc Med, Columbus, OH USA

来源：

JACC-HEART FAILURE | 2024年 / 12卷 / 01期

关键词：

endpoints; heart failure; hospitalization; mortality; RELAX-AHF; MANAGEMENT; SERELAXIN; PATHOPHYSIOLOGY; HOSPITALIZATION; CLASSIFICATION; NESIRITIDE; CARDIOLOGY; MORTALITY; OUTCOMES;

D O I：

10.1016/j.jchf.2023.09.030

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute decompensated heart failure (ADHF) is one of the most common reasons for hospitalizations or urgent care and is associated with poor outcomes. Therapies shown to improve outcomes are limited, however, and innovation in pharmacologic and device -based therapeutics are therefore actively being sought. Standardizing definitions for ADHF and its trajectory is complex, limiting the generalizability and translation of clinical trials to effect clinical care and policy change. The Heart Failure Collaboratory is a multistakeholder organization comprising clinical investigators, clinicians, patients, government representatives (including U.S. Food and Drug Administration and National Institutes of Health participants), payors, and industry collaborators. The following expert consensus document is the product of the Heart Failure Collaboratory convening with the Academic Research Consortium, including members from academia, the U.S. Food and Drug Administration, and industry, for the purposes of proposing standardized definitions for ADHF and highlighting important endpoint considerations to inform the design and conduct of clinical trials for drugs and devices in this clinical arena. (J Am Coll Cardiol HF 2024;12:1-15) (c) 2024 by the American College of Cardiology Foundation.

引用

页码：1 / 15

页数：15

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