A Kinetic Investigation of the Supramolecular Chiral Self-Assembling Process of Cationic Organometallic (2,2′:6′,2"-terpyridine)methylplatinum(II) Complexes with Poly(L-glutamic Acid)

被引：1

作者：

Castriciano, Maria Angela ^{[1
]}

Zagami, Roberto ^{[1
]}

Mazzaglia, Antonino ^{[2
]}

Romeo, Andrea ^{[1
,2
]}

Scolaro, Luigi Monsu ^{[1
,2
]}

机构：

[1] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, Vle F Stagno DAlcontres 31, I-98166 Messina, Italy

[2] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, CNR ISMN Ist Studio Mat Nanostrutturati, Vle F Stagno DAlcontres 31, I-98166 Messina, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 02期

关键词：

platinum(II) complexes; supramolecular adducts; chirality; kinetics of aggregation; RESONANCE LIGHT-SCATTERING; WATER-SOLUBLE PORPHYRINS; PLATINUM(II) COMPLEXES; NUCLEIC-ACIDS; HYDRODYNAMIC-FORCES; NANOSTRUCTURES; CHEMISTRY; VORTICES; POLYMERS; SYSTEMS;

D O I：

10.3390/ijms25021176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cationic platinum(II) organometallic complex [Pt(terpy)Me]+ (terpy = 2,2 ':6 ',2 ''-terpyridine) at mild acidic pH interacts with poly(L-glutamic acid) (L-PGA) in its alpha-helix conformation, affording chiral supramolecular adducts. Their kinetics of formation have been investigated in detail as a function of the concentrations of both reagents and changing pH, ionic strength, the length of the polymeric scaffold and temperature. After a very fast early stage, the kinetic traces have been analyzed as three consecutive steps, suggesting a mechanism based on the electrostatic fast formation of a not-organized aggregate that subsequently evolves through different rearrangements to form the eventual supramolecular adduct. A model for this species has been proposed based on (i) the attractive electrostatic interaction of the cationic platinum(II) complexes and the polyelectrolyte and (ii) the pi-stacking interactions acting among the [Pt(terpy)Me]+ units.

引用

页数：15

共 55 条

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