Occupational anaphylaxis-Data from the anaphylaxis registry

被引：12

作者：

Worm, Margitta ^{[1
,2
,3
,11
]}

Hoefer, Veronika ^{[1
,2
,3
]}

Doelle-Bierke, Sabine ^{[1
,2
,3
]}

Bilo, Maria Beatrice ^{[4
,5
]}

Hartmann, Karin ^{[6
,7
,8
]}

Sabouraud-Leclerc, Dominique ^{[9
]}

Treudler, Regina ^{[10
]}

机构：

[1] Charite Univ Med Berlin, Dept Dermatol Venereol & Allergol, Div Allergy & Immunol, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy

[5] Univ Hosp Ospedali Riuniti Ancona, Dept Internal Med, Allergy Unit, Torrette, Italy

[6] Univ Hosp Basel, Dept Dermatol, Div Allergy, Basel, Switzerland

[7] Univ Basel, Basel, Switzerland

[8] Univ Hosp Basel, Dept Biomed, Basel, Switzerland

[9] Serv Pediat A, Praticien Hospitalier, Pediatre Allergologue, Pole Femme Parents Enfant,AMH 2, Reims, France

[10] Univ klinikum Leipzig, Dept Dermatol Venereol & Allergol, Leipzig, Germany

[11] Charite Univ Med Berlin, Dept Dermatol & Allergol, Div Allergy & Immunol, Charitepl 1, D-10117 Berlin, Germany

来源：

ALLERGY | 2024年 / 79卷 / 03期

关键词：

food allergy; drugs; latex; occupational anaphylaxis; venom; HYMENOPTERA VENOM ALLERGY; BUMBLEBEE VENOM; BEE VENOM; SENSITIZATION; DIAGNOSIS; EXPOSURE;

D O I：

10.1111/all.15974

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BackgroundEpidemiologic data on occupational anaphylaxis is scarce, and there is a need of more knowledge about work-related anaphylactic episodes.MethodsBased on the data of the Anaphylaxis Registry, we identified cases related to occupational exposure and analyzed the elicitors, demographics, severity of clinical reaction and management.ResultsSince 2017, 5851 cases with an information about the occupational relation of the anaphylactic episode were registered whereby 225 (3.8%) were assigned to be caused by an occupational allergen. The vast majority of these occupational anaphylaxis cases were caused by insects (n = 186, 82.7%) followed by food (n = 27, 12.0%) and drugs (n = 8, 3.6%). Latex elicited occupational anaphylaxis in only two cases. Beekeepers, gardeners, farmers, and individuals working in professions associated with food handling, for example, employees in restaurants, bakery, pastry, and cooks were most frequently affected. The comparison of the occupational insect venom-induced anaphylaxis to a group of non-occupational insect anaphylaxis in adults (n = 1842) revealed a significant younger age in occupational anaphylaxis (46 vs. 53 years), a predominance of bee-induced cases (38% vs. 17%), and a higher rate of venom immunotherapy in a primary care setting (3.3% vs. 1.3%, p = .044). In the occupational- versus non-occupational adults with food-induced anaphylaxis atopic dermatitis as concomitant atopic disease was observed more frequently (n = 486; 20% vs. 10%), although this was not significant.ConclusionOur data demonstrate the impact of venom allergy in work-related anaphylaxis. Foods and drugs are less frequently elicitors, and latex-induced occupational anaphylaxis was rare. More data are needed to determine risk factors associated with occupational anaphylaxis. Insect venom, followed by food were the most frequent elicitors of occupational anaphylaxis. Anaphylaxis to bee venom was more frequent in occupational anaphylaxis than non-occupational anaphylaxis in adults. Occupational anaphylaxis to drugs was rare and most frequently induced by antibiotics. Only two occupational cases were latex-induced. Beekeepers, outdoor workers (e.g., gardeners), and farmers were the most frequently affected occupations.image

引用

页码：702 / 710

页数：9

共 34 条

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