Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution

被引：0

作者：

Petkovic, Milos ^{[1
]}

Kusljevic, Dusica ^{[1
]}

Jovanovic, Milos ^{[1
]}

Jovanovic, Predrag ^{[1
]}

Tasic, Gordana ^{[1
]}

Simic, Milena ^{[1
]}

Savic, Vladimir ^{[1
]}

机构：

[1] Univ Belgrade, Fac Pharm, Dept Organ Chem, Vojvode Stepe 450, Belgrade 11221, Serbia

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 03期

关键词：

piperizinones; cyclization reactions; allenes; nucleophilic substitution; combinatorial synthesis; HETEROCYCLIC SCAFFOLDS; NITROGEN-HETEROCYCLES; PIPERAZINONES; AMINATION; DRUGS;

D O I：

10.1055/a-2201-9951

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies.

引用

页码：418 / 426

页数：9

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