Intrathecal chemotherapy for the management of lymphoblastic lymphoma in a 4-year-old dog: a case report
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作者:
Lyseight, Filipa Louise Simoes
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Linnaeus Vet Ltd, Oncol Serv, Dick White Referrals, Shirley, Cambs, EnglandLinnaeus Vet Ltd, Oncol Serv, Dick White Referrals, Shirley, Cambs, England
Lyseight, Filipa Louise Simoes
[1
]
Dupont, Christophe Osterreicher Cunha
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Linnaeus Vet Ltd, Dick White Referrals, Neurol & Neurosurg Serv, Solihull, Cambs, EnglandLinnaeus Vet Ltd, Oncol Serv, Dick White Referrals, Shirley, Cambs, England
Dupont, Christophe Osterreicher Cunha
[2
]
Cherubini, Giunio Bruto
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Linnaeus Vet Ltd, Dick White Referrals, Neurol & Neurosurg Serv, Solihull, Cambs, England
Univ Pisa, Dept Vet Sci, Pisa, ItalyLinnaeus Vet Ltd, Oncol Serv, Dick White Referrals, Shirley, Cambs, England
Cherubini, Giunio Bruto
[2
,3
]
机构:
[1] Linnaeus Vet Ltd, Oncol Serv, Dick White Referrals, Shirley, Cambs, England
[2] Linnaeus Vet Ltd, Dick White Referrals, Neurol & Neurosurg Serv, Solihull, Cambs, England
Intrathecal chemotherapy is used in human medicine for the treatment or prophylaxis of CNS hematopoietic neoplasia. However, the clinical benefits in veterinary medicine have been scarcely documented. A 4-year-old male entire cross-breed dog presented with a 24-h history of severe lethargy, pelvic limb weakness, and urinary retention. Examination revealed generalized peripheral lymphadenomegaly, and the neurological findings were suggestive of a myelopathy in the region of T3-L3. Following the diagnosis of multicentric lymphoblastic B-cell lymphoma (stage Vb), a modified L-LOP with cytosine arabinoside was started, and complete clinical remission was achieved. After 4 weeks, there was acute neurological deterioration (spinal pain and proprioceptive deficits) without peripheral lymphadenomegaly. MRI findings and CSF analysis were consistent with meningeal and spinal cord lymphoma infiltration at the level of L3. Intrathecal chemotherapy (cytosine arabinoside and methotrexate) were administered in the cisterna magna with systemic dexamethasone and analgesia. Clinical signs were resolved within 24 h, and the patient remained asymptomatic for 3.5 weeks. After this period, CNS relapse (proprioceptive deficits and severe thoracolumbar pain) was suspected, and repeat intrathecal chemotherapy was declined. The patient was humanely euthanized 9 weeks after the initial diagnosis. This is the first report on the clinical benefit of intrathecal chemotherapy with a combination of methotrexate and cytarabine for the management of CNS lymphoma in dogs. Based on our case, intrathecal chemotherapy with methotrexate and cytarabine can induce a short-lasting CNS clinical remission (3 weeks).
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Iran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
Moshfegh, Fereshteh
Hosseinzade, Zahra
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Iran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
Hosseinzade, Zahra
Javanbakht, Mohammad
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Baqiyatallah Univ Med Sci, Clin Sci Inst, Nephrol & Urol Res Ctr, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
Javanbakht, Mohammad
Ansari, Shahla
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Iran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
Ansari, Shahla
Anari, Ali Manafi
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Iran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
Anari, Ali Manafi
Tavajohi, Khatere
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Iran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Hematol, Tehran, IranIran Univ Med Sci, Ali Asghar Children Hosp, Dept Pediat, Pediat Intens Care Unit, Tehran, Iran
机构:Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
Cheon, JS
You, YK
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Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South KoreaCatholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
You, YK
Kim, JG
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机构:Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
Kim, JG
Lee, DH
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机构:Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
Lee, DH
Park, K
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机构:Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
Park, K
Ahn, CJ
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机构:Catholic Univ Korea, Coll Med, Daejeon St Marys Hosp, Dept Surg, Taejon 301723, South Korea
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Univ Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R ChinaUniv Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R China
Yao, Jia-Wei
Qiu, Li
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West China Second Univ Hosp Sichuan Univ, Div Pediat Pulmonol & Immunol, Key Lab Birth Defects & Related Dis Women & Childr, NHC Key Lab Chronobiol, Chengdu 610041, Sichuan, Peoples R ChinaUniv Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R China
Qiu, Li
Liang, Ping
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West China Second Univ Hosp Sichuan Univ, Div Pediat Pulmonol & Immunol, Key Lab Birth Defects & Related Dis Women & Childr, NHC Key Lab Chronobiol, Chengdu 610041, Sichuan, Peoples R ChinaUniv Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R China
Liang, Ping
Liu, Han-Min
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West China Second Univ Hosp Sichuan Univ, Div Pediat Pulmonol & Immunol, Key Lab Birth Defects & Related Dis Women & Childr, NHC Key Lab Chronobiol, Chengdu 610041, Sichuan, Peoples R ChinaUniv Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R China
Liu, Han-Min
Chen, Li-Na
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West China Second Univ Hosp Sichuan Univ, Div Pediat Pulmonol & Immunol, Key Lab Birth Defects & Related Dis Women & Childr, NHC Key Lab Chronobiol, Chengdu 610041, Sichuan, Peoples R China
West China Second Univ Hosp Sichuan Univ, Div Pediat Pulmonol & Immunol, Key Lab Birth Defects & Related Dis Women & Childr, NHC Key Lab Chronobiol, 20 Sect 3 South Renmin Rd, Chengdu 610041, Sichuan, Peoples R ChinaUniv Elect Sci & Technol China, Chengdu Womens & Childrens Cent Hosp, Sch Med, Div Pediat Pulmonol, Chengdu 610091, Sichuan, Peoples R China
机构:
Univ Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, SloveniaUniv Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
Arkar, Ula
Vipotnik Vesnaver, Tina
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Univ Med Ctr Ljubljana, Dept Radiol, Ljubljana, SloveniaUniv Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
Vipotnik Vesnaver, Tina
Osredkar, Damjan
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Univ Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
Univ Ljubljana, Fac Med, Ctr Dev Neurosci, Ljubljana, SloveniaUniv Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
Osredkar, Damjan
Perkovic Benedik, Mirjana
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Univ Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, SloveniaUniv Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia
Perkovic Benedik, Mirjana
Bizjak, Neli
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Univ Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, SloveniaUniv Childrens Hosp, Univ Med Ctr Ljubljana, Dept Child Adolescent & Dev Neurol, Ljubljana, Slovenia