[1] Univ Toronto, Toronto, ON, Canada
[2] Unity Hlth Toronto, Toronto, ON, Canada
[3] IRCCS Humanitas Res Hosp, Dept Gastroenterol, Rozzano, Italy
[4] Univ Roma Tor Vergata, Tor Vergata, Italy
[5] Portsmouth Hosp Univ NHS Trust, Portsmouth, Hants, England