Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence

被引：8

作者：

Weerasinghe-Mudiyanselage, Poornima D. E. ^{[1
,2
]}

Kang, Sohi ^{[1
,2
]}

Kim, Joong-Sun ^{[1
,2
]}

Moon, Changjong ^{[1
,2
,3
,4
]}

机构：

[1] Chonnam Natl Univ, Coll Vet Med, Dept Vet Anat & Anim Behav, Gwangju 61186, South Korea

[2] Chonnam Natl Univ, BK21 FOUR Program, Gwangju 61186, South Korea

[3] Chonnam Natl Univ, Coll Vet Med, Dept Vet Anat & Anim Behav, 77 Yongbong Ro, Gwangju 61186, South Korea

[4] Chonnam Natl Univ, BK21 FOUR Program, 77 Yongbong Ro, Gwangju 61186, South Korea

来源：

CURRENT NEUROPHARMACOLOGY | 2023年 / 21卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Non-motor symptoms; Parkinson's disease; patients' quality of life; preclinical models; therapeutics; rapid eye movement (REM); DEEP BRAIN-STIMULATION; METABOTROPIC GLUTAMATE RECEPTORS; DEPRESSIVE-LIKE BEHAVIOR; MILD COGNITIVE IMPAIRMENT; MONOAMINE-OXIDASE-B; QUALITY-OF-LIFE; ALPHA-SYNUCLEIN; ADENOSINE A(2A); RAT MODEL; MOUSE MODEL;

D O I：

10.2174/1570159X20666221005090126

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite being classified as a movement disorder, Parkinson's disease (PD) is characterized by a wide range of non-motor symptoms that significantly affect the patients' quality of life. However, clear evidence-based therapy recommendations for non-motor symptoms of PD are uncommon. Animal models of PD have previously been shown to be useful for advancing the knowledge and treatment of motor symptoms. However, these models may provide insight into and assess therapies for non-motor symptoms in PD. This paper highlights non-motor symptoms in preclinical models of PD and the current position regarding preclinical therapeutic approaches for these non-motor symptoms. This information may be relevant for designing future preclinical investigations of therapies for non-motor symptoms in PD.

引用

页码：560 / 577

页数：18

共 230 条

[1] Cognitive decline in Parkinson disease [J].