A Straightforward Synthesis of Emericellamide A Using Matteson's Homologation Approach

被引：2

作者：

Priester, Ronja ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Saarland Univ, Organ Chem, D-66123 Saarbrucken, Germany

来源：

SYNLETT | 2023年 / 34卷 / 18期

关键词：

boronic esters; Matteson homologation; natural products; peptides; stereoselective synthesis; ANTI-ALDOL REACTIONS; BORONIC ESTERS; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; ESTERIFICATION; SELECTIVITY;

D O I：

10.1055/a-2077-2113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Matteson homologation is the perfect approach for the synthesis of polyketide-peptide natural products such as the emericellamides. In only four steps, the polyketide fragment with three stereo genic centers can be obtained as a single stereoisomer. The peptide fragment is easily available via solid-phase peptide synthesis.

引用

页码：2159 / 2164

页数：6

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