Methotrexate-induced Neutropenia

被引：0

作者：

Parmar, Kesha Ajaykumar ^{[1
,2
]}

Mehta, Maulin D. ^{[1
]}

机构：

[1] Shrimati Bhikhiben Kanjibhai Shah Med Inst & Res C, Dept Pharmacol, Vadodara, Gujarat, India

[2] 31 FF Shri Krishna Kunj Soc,Jetalpur Rd, Vadodara 390007, Gujarat, India

来源：

ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE | 2023年 / 15卷 / 01期

关键词：

Adverse drug reaction; oral lesions; rheumatoid arthritis; THERAPY;

D O I：

10.4103/ajprhc.ajprhc_15_23

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Various malignancies, autoimmune disorders such as rheumatoid arthritis (RA), and elective abortions commonly use methotrexate (MTX) for their treatment, which is a folate antagonist. Although many cases of the common side effects of MTX such as nausea, vomiting, and stomatitis have been reported, very few cases of MTX-induced neutropenia have been found in the literature. We have taken a case of neutropenia that developed after the patient took tablet MTX for RA. The case was studied and the causality assessment of the reported adverse drug reaction showed it to be in the category of "probable" according to the WHO-UMC causality categories.

引用

页码：105 / 107

页数：3

共 11 条

[1] How does methotrexate work? [J].

Alqarni, Adel M. ;

Zeidler, Martin P. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2020, 48 (02) :559-567

[2] The use of methotrexate in rheumatoid arthritis [J].

Borchers, AT ;

Keen, CL ;

Cheema, GS ;

Gershwin, ME .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2004, 34 (01) :465-483

[3]

Chabner B, 2015, GOODMAN GILMANS PHAR, V12th, P6

[4] Methotrexate mechanism in treatment of rheumatoid arthritis [J].

Friedman, Benjamin ;

Cronstein, Bruce .

JOINT BONE SPINE, 2019, 86 (03) :301-307

[5] Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis [J].

GutierrezUrena, S ;

Molina, JF ;

Garcia, CO ;

Cuellar, ML ;

Espinoza, LR .

ARTHRITIS AND RHEUMATISM, 1996, 39 (02) :272-276

[6] The treatment of inflammatory arthritis with methotrexate in clinical practice: treatment duration and incidence of adverse drug reactions [J].

Kinder, AJ ;

Hassell, AB ;

Brand, J ;

Brownfield, A ;

Grove, M ;

Shadforth, MF .

RHEUMATOLOGY, 2005, 44 (01) :61-66

[7]

Kwoh CK, 1996, ARTHRITIS RHEUM-US, V39, P713

[8] METHOTREXATE - MECHANISM OF ACTION IN RHEUMATOID-ARTHRITIS [J].

SEGAL, R ;

YARON, M ;

TARTAKOVSKY, B .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 1990, 20 (03) :190-199

[9]

Simms RW, 1996, ARTHRITIS RHEUM-US, V39, P723

[10] EFFICACY OF LOW-DOSE METHOTREXATE IN RHEUMATOID-ARTHRITIS [J].

WEINBLATT, ME ;

COBLYN, JS ;

FOX, DA ;

FRASER, PA ;

HOLDSWORTH, DE ;

GLASS, DN ;

TRENTHAM, DE .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (13) :818-822

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