Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network

被引：3

作者：

Zambrano, Laura D. ^{[1
,42
]}

Newhams, Margaret M. ^{[2
]}

Simeone, Regina M. ^{[1
]}

Fleming-Dutra, Katherine E. ^{[1
]}

Halasa, Natasha ^{[3
]}

Wu, Michael ^{[1
]}

Orzel-Lockwood, Amber O. ^{[2
]}

Kamidani, Satoshi ^{[4
,5
]}

Pannaraj, Pia S. ^{[6
,7
]}

Chiotos, Kathleen ^{[8
]}

Cameron, Melissa A. ^{[9
]}

Maddux, Aline B. ^{[10
,11
]}

Schuster, Jennifer E. ^{[12
]}

Crandall, Hillary ^{[13
,14
]}

Kong, Michele ^{[15
]}

Nofziger, Ryan A. ^{[16
]}

Staat, Mary A. ^{[17
]}

Bhumbra, Samina S. ^{[18
]}

Irby, Katherine ^{[19
]}

Boom, Julie A. ^{[20
]}

Sahni, Leila C. ^{[20
]}

Hume, Janet R. ^{[21
]}

Gertz, Shira J. ^{[22
]}

Maamari, Mia ^{[23
]}

Bowens, Cindy ^{[23
]}

Levy, Emily R. ^{[24
,25
]}

Bradford, Tamara T. ^{[26
,27
]}

Walker, Tracie C. ^{[28
]}

Schwartz, Stephanie P. ^{[28
]}

Mack, Elizabeth H. ^{[29
]}

Guzman-Cottrill, Judith A. ^{[30
]}

Hobbs, Charlotte V. ^{[31
,32
]}

Zinter, Matt S. ^{[33
,34
,35
]}

Cvijanovich, Natalie Z. ^{[36
]}

Bline, Katherine E. ^{[37
]}

Hymes, Saul R. ^{[38
]}

Campbell, Angela P. ^{[1
,43
]}

Randolph, Adrienne G. ^{[2
,39
,40
,41
]}

机构：

[1] Ctr Dis Control & Prevent, Coronavirus & Other Resp Viruses Div, Atlanta, GA USA

[2] Boston Childrens Hosp, Dept Anesthesiol Crit Care & Pain Med, Boston, MA USA

[3] Vanderbilt Univ, Med Ctr, Dept Pediat, Div Pediat Infect Dis, Nashville, TN 37232 USA

[4] Ctr Childhood Infect & Vaccines, Childrens Healthcare Atlanta, Atlanta, GA USA

[5] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[6] Childrens Hosp Los Angeles, Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

[7] Univ Southern Calif, Childrens Hosp Los Angeles, Dept Mol Microbiol & Immunol, Div Infect Dis, Los Angeles, CA USA

[8] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care, Div Crit Care Med, Philadelphia, PA 19104 USA

[9] Div Pediat Hosp Med, UC San Diego Rady Childrens Hosp, San Diego, CA USA

[10] Univ Colorado, Sch Med, Dept Pediat, Sect Crit Care Med, Aurora, CO USA

[11] Childrens Hosp Colorado, Aurora, CO USA

[12] Dept Pediat, Div Pediat Infect Dis, Childrens Mercy Kansas City, Kansas City, MO USA

[13] Univ Utah, Dept Pediat, Div Pediat Crit Care, Salt Lake City, UT USA

[14] Primary Childrens Med Ctr, Salt Lake City, UT USA

[15] Univ Alabama Birmingham, Dept Pediat, Div Pediat Crit Care Med, Birmingham, AL USA

[16] Akron Childrens Hosp, Dept Pediat, Div Crit Care Med, Akron, OH USA

[17] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Dept Pediat, Cincinnati, OH USA

[18] Indiana Univ Sch Med, Ryan White Ctr Pediat Infect Dis & Global Hlth, Dept Pediat, Indianapolis, IN USA

[19] Arkansas Childrens Hosp, Dept Pediat, Sect Pediat Crit Care, Little Rock, AR USA

[20] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Immunizat Project, Houston, TX USA

[21] Univ Minnesota, Masonic Childrens Hosp, Div Pediat Crit Care, Minneapolis, MN USA

[22] Cooperman Barnabas Med Ctr, Dept Pediat, Div Pediat Crit Care, Livingston, NJ USA

[23] Univ Texas Southwestern, Childrens Med Ctr Dallas, Dept Pediat, Div Crit Care Med, Texas, Mexico

[24] Dept Pediat & Adolescent Med, Div Pediat Infect Dis, Mayo Clin, Rochester, MN USA

[25] Dept Pediat & Adolescent Med, Div Pediat Crit Care Med, Mayo Clin, Rochester, MN USA

[26] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, Div Cardiol, New Orleans, LA USA

[27] Childrens Hosp New Orleans, New Orleans, LA USA

[28] Univ North Carolina Chapel Hill, Dept Pediat, Childrens Hosp, Chapel Hill, NC USA

[29] Med Univ South Carolina, Div Pediat Crit Care Med, Charleston, SC USA

[30] Oregon Hlth & Sci Univ, Dept Pediat, Div Infect Dis, Portland, OR 97201 USA

[31] Univ Mississippi, Med Ctr, Dept Pediat, Div Infect Dis,Childrens Mississippi, Jackson, MS USA

[32] Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Childrens Mississippi, Jackson, MS USA

[33] Univ Calif San Francisco, Dept Pediat, Div Crit Care Med & Allergy, San Francisco, CA USA

[34] Univ Calif San Francisco, Dept Pediat, Div Immunol, San Francisco, CA USA

[35] Univ Calif San Francisco, Dept Pediat, Div Bone Marrow Transplant, San Francisco, CA USA

[36] UCSF Benioff Childrens Hosp Oakland, Div Pediat Crit Care Med, Oakland, CA USA

[37] Nationwide Childrens Hosp, Div Pediat Crit Care Med, Columbus, OH 43205 USA

[38] Bernard & Millie Duker Childrens Hosp, Dept Pediat, Div Pediat Infect Dis, Albany Med Hlth Syst, Albany, NY USA

[39] Harvard Med Sch, Dept Anaesthesia, Boston, MA USA

[40] Harvard Med Sch, Dept Pediat, Boston, MA USA

[41] Harvard Med Sch, Dept Pediat, Boston, MA USA

[42] US Ctr Dis Control & Prevent, Clifton Rd NE,MS 24-9, Atlanta, GA 30329 USA

[43] Ctr Dis Control & Prevent, Coronavirus & Other Resp Viruses Div, Atlanta, GA 30329 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2024年 / 43卷 / 03期

关键词：

COVID-19; vaccination; vaccine coverage; under-5; years; clinical outcomes; 6; MONTHS-5; YEARS; UNITED-STATES; INFANTS;

D O I：

10.1097/INF.0000000000004225

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background and objectives: In June 2022, the mRNA COVID-19 vaccination was recommended for young children. We examined clinical characteristics and factors associated with vaccination status among vaccine-eligible young children hospitalized for acute COVID-19. Methods: We enrolled inpatients 8 months to <5 years of age with acute community-acquired COVID-19 across 28 US pediatric hospitals from September 20, 2022 to May 31, 2023. We assessed demographic and clinical factors, including the highest level of respiratory support, and vaccination status defined as unvaccinated, incomplete, or complete primary series [at least 2 (Moderna) or 3 (Pfizer-BioNTech) mRNA vaccine doses >= 14 days before hospitalization]. Results: Among 597 children, 174 (29.1%) patients were admitted to the intensive care unit and 75 (12.6%) had a life-threatening illness, including 51 (8.5%) requiring invasive mechanical ventilation. Children with underlying respiratory and neurologic/neuromuscular conditions more frequently received higher respiratory support. Only 4.5% of children hospitalized for COVID-19 (n = 27) had completed their primary COVID-19 vaccination series and 7.0% (n = 42) of children initiated but did not complete their primary series. Among 528 unvaccinated children, nearly half (n = 251) were previously healthy, 3 of them required extracorporeal membrane oxygenation for acute COVID-19 and 1 died. Conclusions: Most young children hospitalized for acute COVID-19, including most children admitted to the intensive care unit and with life-threatening illness, had not initiated COVID-19 vaccination despite being eligible. Nearly half of these children had no underlying conditions. Of the small percentage of children who initiated a COVID-19 primary series, most had not completed it before hospitalization.

引用

页码：242 / 249

页数：8

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