Reversibility of Bicalutamide PSMA PET-Positive Gynecomastia With Androgen Deprivation Therapy

被引：2

作者：

Muniz, Miguel ^{[1
]}

Childs, Daniel S. ^{[1
]}

Orme, Jacob J. ^{[1
]}

Johnson, Geoffrey B. ^{[2
,3
]}

Sartor, Oliver ^{[1
]}

机构：

[1] Mayo Clin, Div Med Oncol, Dept Radiol, Rochester, MN USA

[2] Mayo Clin, Dept Radiol, Div Nucl Med, Rochester, MN USA

[3] Mayo Clin, Dept Immunol, Rochester, MN USA

来源：

CLINICAL NUCLEAR MEDICINE | 2024年 / 49卷 / 04期

关键词：

PSMA PET/CT; gynecomastia; bicalutamide; androgen deprivation therapy; metastatic prostate cancer;

D O I：

10.1097/RLU.0000000000005084

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 78-year-old man receiving bicalutamide for prostate cancer was referred for a PSMA PET/CT scan to evaluate his gradually rising prostate-specific antigen level. The PSMA PET/CT revealed gynecomastia with radiotracer uptake in bilateral breast parenchyma, a known but rarely reported effect of bicalutamide monotherapy. This scan also demonstrated metastatic progression of his disease in bone and lymph nodes, and he was started on leuprolide injections. Three months after a decrease in his testosterone level, the radiotracer uptake in his breast tissue had resolved, demonstrating that PSMA-avid bicalutamide-induced gynecomastia is reversible.

引用

页码：e164 / e165

页数：2

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