A solid-state NMR method for characterization of pharmaceutical eutectics

被引：4
作者：
Hareendran, Chaithanya [1 ,2 ,3 ]
Shaligram, Parth S. [2 ,3 ]
Gonnade, Rajesh [2 ,3 ]
Ajithkumar, T. G. [1 ,2 ,3 ]
机构：
[1] CSIR Natl Chem Lab, Cent NMR Facil, Pune 411008, Maharashtra, India
[2] CSIR Natl Chem Lab, Phys Mat Chem Div, Pune 411008, Maharashtra, India
[3] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2024年 / 26卷 / 05期
关键词：
NUCLEAR-MAGNETIC-RESONANCE; IDENTIFICATION; SOLVENTS; ACID;
D O I：
10.1039/d3cp05615e
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions. 2D 1H-1H double quantum single quantum (DQSQ) correlation SSNMR experiment is demonstrated which can confirm the formation of pharmaceutical eutectics for which there are no techniques other than differential scanning calorimetry (DSC).
引用
收藏
页码：3800 / 3803
页数：4
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