Role of percutaneous CT-guided biopsy in the characterisation of pleural diseases

被引:1
作者
Pasha, Iram [1 ]
Singh, Anil K. [1 ]
Hashim, Zia [2 ]
Nath, Alok [2 ]
Neyaz, Zafar [1 ,5 ]
Mishra, Richa [3 ]
Agrawal, Vinita [4 ]
机构
[1] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Dept Radiodiag, Raebareli Rd, Lucknow, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Dept Pulm Med, Lucknow, Uttar Pradesh, India
[3] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Dept Microbiol, Lucknow, Uttar Pradesh, India
[4] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Dept Pathol, Raebareli Rd, Lucknow, Uttar Pradesh, India
[5] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Dept Radiodiag, Raebareli Rd, Lucknow 226014, Uttar Pradesh, India
关键词
Adenocarcinoma; biopsy; CT-guided; metastasis; percutaneous; pleura; DIAGNOSIS; EFFUSION;
D O I
10.4103/lungindia.lungindia_164_23
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background: Computed tomography (CT)-guided biopsy is emerging as a preferred and safe method for obtaining tissue samples in pleural diseases. Objective: This study aimed to evaluate the diagnostic yield and safety of percutaneous CT-guided biopsy in pleural diseases and to find CT findings predictive of malignant neoplastic pleural disease. Material and Methods: This retrospective study included 77 patients with pleural disease who underwent CT-guided pleural biopsies from July 2013 to May 2020. All procedures were performed with a coaxial semi-automatic biopsy device. Histopathology was performed in all cases, and additional tests such as immunohistochemistry (IHC) or microbiological analysis were carried out depending on clinical suspicion. The correlation of CT findings with final diagnosis was performed by Chi-square, Fisher's exact test and logistic regression analysis. Results: The overall technical success rate of CT-guided pleural biopsy was 100% with a diagnostic yield of 96.1%. No major complication was encountered, with minor complications encountered in the form of minimal pneumothorax and chest pain. Malignant pleural conditions constituted the largest group including metastatic adenocarcinoma as the most common (31.2%), followed by metastatic squamous cell carcinoma and mesothelioma. Tubercular pleural involvement was the second most common category (16.9%). The cartridge-based nucleic acid amplification test (CB-NAAT) assay had 90% sensitivity on pleural tissue in tubercular cases. CT features predictive of malignancy were irregular and nodular pleural thickening, mediastinal and diaphragmatic pleural involvement and mediastinal/chest wall invasion. There was a good correlation between higher pleural thicknesses with malignant outcome. Conclusion: Percutaneous CT-guided biopsy is a safe method for obtaining pleural tissue samples with high diagnostic yield. CT findings provide clues, which favour malignant pleural involvement.
引用
收藏
页码:514 / 520
页数:7
相关论文
共 15 条
[1]   Computed tomography-guided cutting needle pleural biopsy: Accuracy and complications [J].
Cao, Yi-Yuan ;
Fan, Na ;
Xing, Fen ;
Xu, Li-Ying ;
Qu, Yan-Juan ;
Liao, Mei-Yan .
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015, 9 (01) :262-266
[2]   Diagnosis of tuberculous pleural effusions: A review [J].
Cascio, Christian M. Lo ;
Kaul, Viren ;
Dhooria, Sahajal ;
Agrawal, Abhinav ;
Chaddha, Udit .
RESPIRATORY MEDICINE, 2021, 188
[3]   Malignant pleural disease: a pragmatic guide to diagnosis [J].
Chang, Christopher H. ;
Ost, David E. .
CURRENT OPINION IN PULMONARY MEDICINE, 2022, 28 (04) :282-287
[4]   Imaging Approach to Disease of the Pleura [J].
Eibschutz, Liesl S. ;
Flors, Lucia ;
Taravat, Farzaneh ;
Gholamrezanezhad, Ali .
SEMINARS IN NUCLEAR MEDICINE, 2022, 52 (06) :797-805
[5]   Pleural neoplastic pathology [J].
Karpathiou, Georgia ;
Stefanou, Dimitrios ;
Froudarakis, Marios E. .
RESPIRATORY MEDICINE, 2015, 109 (08) :931-943
[6]   Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea [J].
Kim, Yoon Kyung ;
Kim, Jeung Sook ;
Lee, Kyung Won ;
Yi, Chin A. ;
Koo, Jin Mo ;
Jung, Soon-Hee .
KOREAN JOURNAL OF RADIOLOGY, 2016, 17 (04) :545-553
[7]   Pleural controversy: Close needle pleural biopsy or thoracoscopy-Which first? [J].
Koegelenberg, Coenraad F. N. ;
Diacon, Andreas H. .
RESPIROLOGY, 2011, 16 (05) :738-746
[8]   CT IN DIFFERENTIAL-DIAGNOSIS OF DIFFUSE PLEURAL DISEASE [J].
LEUNG, AN ;
MULLER, NL ;
MILLER, RR .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1990, 154 (03) :487-492
[9]  
Manu MK., 2014, BMJ Case Rep, V2014, pbcr2013201754
[10]   IMAGING THE PLEURA - SONOGRAPHY, CT, AND MR IMAGING [J].
MCLOUD, TC ;
FLOWER, CDR .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1991, 156 (06) :1145-1153