BARFV600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

被引：13

作者：

Acosta-Medina, Aldo A. ^{[1
,2
]}

Kemps, Paul G.

Zondag, Timo C. E. ^{[3
,4
]}

Abeykoon, Jithma P. ^{[2
]}

Forma-Borst, Jelske ^{[5
]}

Steenwijk, Eline C. ^{[5
]}

Feijen, Elizabeth A. M. ^{[6
]}

Teepen, Jop C. ^{[6
]}

Bennani, N. Nora ^{[2
]}

Schram, Susan M. ^{[2
]}

Shah, Mithun, V ^{[2
]}

Davidge-Pitts, Caroline ^{[7
]}

Koster, Matthew J. ^{[8
]}

Ryu, Jay H. ^{[9
]}

Vassallo, Robert

Tobin, W. Oliver ^{[10
]}

Young, Jason R. ^{[11
]}

Dasari, Surendra ^{[12
]}

Rech, Karen ^{[13
]}

Ravindran, Aishwarya ^{[14
]}

Cleven, Arjen H. G. ^{[3
,15
]}

Verdijk, Robert M. ^{[3
,16
]}

van Noesel, Carel J. M. ^{[17
]}

Balgobind, Brian, V ^{[18
]}

Bouma, Gerrit Joan ^{[19
]}

Saeed, Peerooz ^{[20
]}

Bramer, Jos A. M. ^{[6
,21
]}

de Groen, Ruben A. L. ^{[22
]}

Vermaat, Joost S. P. ^{[22
]}

van de Sande, Michiel A. J. ^{[6
,23
]}

Smit, Egbert F. ^{[24
]}

Langerak, Anton W. ^{[25
]}

van Wezel, Tom ^{[3
]}

Tonino, Sanne H. ^{[26
]}

van den Bos, Cor ^{[6
,27
]}

van Laar, Jan A. M. ^{[3
,4
,28
]}

Go, Ronald S. ^{[2
]}

Goyal, Gaurav ^{[2
]}

van Halteren, Astrid G. S. ^{[3
,4
,6
]}

机构：

[1] Mayo Clin, Dept Internal Med, Rochester, MN USA

[2] Mayo Clin, Div Hematol, Rochester, MN USA

[3] Erasmus Univ, Dept Internal Med, Sect Clin Immunol, Med Ctr Rotterdam, Rotterdam, Netherlands

[4] Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands

[5] Leiden Univ, Med Ctr, Dept Pediat, Leiden, Netherlands

[6] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

[7] Mayo Clin, Div Endocrinol, Rochester, MN USA

[8] Mayo Clin, Div Pulm & Crit Care Med, Rochester, MN USA

[9] Mayo Clin, Div Rheumatol, Rochester, MN USA

[10] Mayo Clin, Dept Neurol, Rochester, MN USA

[11] Mayo Clin, Dept Radiol, Jacksonville, FL USA

[12] Mayo Clin, Dept Quantitat Hlth Sci, Div Biomed Stat & Informat, Rochester, MN USA

[13] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55906 USA

[14] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35233 USA

[15] Univ Med Ctr Groningen, Dept Pathol, Groningen, Netherlands

[16] Erasmus Univ, Med Ctr Rotterdam, Dept Pathol, Rotterdam, Netherlands

[17] Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands

[18] Univ Amsterdam, Med Ctr, Dept Radiat Oncol, Amsterdam, Netherlands

[19] Univ Amsterdam, Med Ctr, Dept Neurosurg, Amsterdam, Netherlands

[20] Univ Amsterdam, Orbital Ctr, Med Ctr, Dept Ophthalmol, Amsterdam, Netherlands

[21] Univ Amsterdam, Med Ctr, Dept Orthoped Surg & Sports Med, Amsterdam, Netherlands

[22] Leiden Univ, Med Ctr, Dept Hematol, Leiden, Netherlands

[23] Leiden Univ, Med Ctr, Dept Orthoped Surg, Leiden, Netherlands

[24] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden, Netherlands

[25] Erasmus Univ, Dept Immunol, Lab Med Immunol, Med Ctr Rotterdam, Rotterdam, Netherlands

[26] Univ Amsterdam, Dept Hematol, Med Ctr, Amsterdam, Netherlands

[27] Univ Amsterdam, Emma Childrens Hosp, Dept Pediat Oncol, Med Ctr, Amsterdam, Netherlands

[28] Erasmus Univ, Dept Immunol, Sect Clin Immunol, Med Ctr Rotterdam, Rotterdam, Netherlands

来源：

BLOOD | 2023年 / 142卷 / 18期

关键词：

RISK;

D O I：

10.1182/blood.2023021212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related. © 2023 The American Society of Hematology

引用

页码：1570 / 1575

页数：6

共 17 条

[1] BRAF testing modalities in histiocytic disorders: Comparative analysis and proposed testing algorithm [J].

Acosta-Medina, Aldo A. ;

Abeykoon, Jithma P. ;

Go, Ronald S. ;

Goyal, Gaurav ;

Ravindran, Aishwarya ;

Schram, Susan M. ;

Rech, Karen L. .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2023, 160 (05) :483-489

[2] The coming of age of Langerhans cell histiocytosis [J].

Allen, Carl E. ;

Beverley, Peter C. L. ;

Collin, Matthew ;

Diamond, Eli L. ;

Egeler, R. Maarten ;

Ginhoux, Florent ;

Glass, Christopher ;

Minkov, Milen ;

Rollins, Barrett J. ;

van Halteren, Astrid .

NATURE IMMUNOLOGY, 2020, 21 (01) :1-7

[3] Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients [J].

Bagnasco, Francesca ;

Zimmermann, Stefanie Yvonne ;

Egeler, Rudolph Maarten ;

Nanduri, Vasanta Rao ;

Cammarata, Bruna ;

Donadieu, Jean ;

Lehrnbecher, Thomas ;

Haupt, Riccardo .

EUROPEAN JOURNAL OF CANCER, 2022, 172 :138-145

[4] Treatment outcomes and prognostic factors of patients with adult Langerhans cell histiocytosis [J].

Cao, Xin-xin ;

Duan, Ming-hui ;

Zhao, Ai-lin ;

Cai, Hao ;

Chen, Jia ;

Gao, Xue-min ;

Liu, Ting ;

Cai, Hua-cong ;

Zhang, Lu ;

Sun, Jian ;

Liang, Zhi-yong ;

Zhou, Dao-bin ;

Li, Jian .

AMERICAN JOURNAL OF HEMATOLOGY, 2022, 97 (02) :203-208

[5] Detection of Clonal Lymphoid Receptor Gene Rearrangements in Langerhans Cell Histiocytosis [J].

Chen, Wei ;

Wang, Jun ;

Wang, Endi ;

Lu, Ying ;

Lau, Sean K. ;

Weiss, Lawrence M. ;

Huang, Qin .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2010, 34 (07) :1049-1057

[6] Spectrum of second primary malignancies and cause-specific mortality in pediatric and adult langerhans cell histiocytosis [J].

Goyal, Gaurav ;

Parikh, Richa ;

Richman, Joshua ;

Abeykoon, Jithma P. ;

Morlote, Diana ;

Go, Ronald S. ;

Bhatia, Smita .

LEUKEMIA RESEARCH, 2023, 126

[7] International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults [J].

Goyal, Gaurav ;

Tazi, Abdellatif ;

Go, Ronald S. ;

Rech, Karen L. ;

Picarsic, Jennifer L. ;

Vassallo, Robert ;

Young, Jason R. ;

Cox, Christian W. ;

Van Laar, Jan ;

Hermiston, Michelle L. ;

Cao, Xin-Xin ;

Makras, Polyzois ;

Kaltsas, Gregory ;

Haroche, Julien ;

Collin, Matthew ;

McClain, Kenneth L. ;

Diamond, Eli L. ;

Girschikofsky, Michael .

BLOOD, 2022, 139 (17) :2601-2621

[8] BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy [J].

Heritier, Sebastien ;

Emile, Jean-Francois ;

Barkaoui, Mohamed-Aziz ;

Thomas, Caroline ;

Fraitag, Sylvie ;

Boudjemaa, Sabah ;

Renaud, Florence ;

Moreau, Anne ;

Peuchmaur, Michel ;

Chassagne-Clement, Catherine ;

Dijoud, Frederique ;

Rigau, Valerie ;

Moshous, Despina ;

Lambilliotte, Anne ;

Mazingue, Francoise ;

Kebaili, Kamila ;

Miron, Jean ;

Jeziorski, Eric ;

Plat, Genevieve ;

Aladjidi, Nathalie ;

Ferster, Alina ;

Pacquement, Helene ;

Galambrun, Claire ;

Brugieres, Laurence ;

Leverger, Guy ;

Mansuy, Ludovic ;

Paillard, Catherine ;

Deville, Anne ;

Armari-Alla, Corinne ;

Lutun, Anne ;

Gillibert-Yvert, Marion ;

Stephan, Jean-Louis ;

Cohen-Aubart, Fleur ;

Haroche, Julien ;

Pellier, Isabelle ;

Millot, Frederic ;

Lescoeur, Brigitte ;

Gandemer, Virginie ;

Bodemer, Christine ;

Lacave, Roger ;

Helias-Rodzewicz, Zofia ;

Taly, Valerie ;

Geissmann, Frederic ;

Donadieu, Jean .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (25) :3023-+

[9] Genetic landscape of adult Langerhans cell histiocytosis with lung involvement [J].

Jouenne, Fanelie ;

Chevret, Sylvie ;

Bugnet, Emmanuelle ;

Clappier, Emmanuelle ;

Lorillon, Gwenael ;

Meignin, Veronique ;

Sadoux, Aurelie ;

Cohen, Shannon ;

Haziot, Alain ;

How-Kit, Alexandre ;

Kannengiesser, Caroline ;

Lebbe, Celeste ;

Gossot, Dominique ;

Mourah, Samia ;

Tazi, Abdellatif .

EUROPEAN RESPIRATORY JOURNAL, 2020, 55 (02)

[10] Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study [J].

Kemps, Paul G. ;

Zondag, Timo C. E. ;

Arnardottir, Helga B. ;

Solleveld-Westerink, Nienke ;

Borst, Jelske ;

Steenwijk, Eline C. ;

van Egmond, Demi ;

Swennenhuis, Joost F. ;

Stelloo, Ellen ;

Trambusti, Irene ;

Verdijk, Robert M. ;

van Noesel, Carel J. M. ;

Cleven, Arjen H. G. ;

Scheijde-Vermeulen, Marijn A. ;

Koudijs, Marco J. ;

Krskova, Lenka ;

Hawkins, Cynthia ;

Egeler, R. Maarten ;

Brok, Jesper ;

Greenwood, Tatiana von Bahr ;

Svojgr, Karel ;

Beishuizen, Auke ;

van Laar, Jan A. M. ;

Poetschger, Ulrike ;

Hutter, Caroline ;

Sieni, Elena ;

Minkov, Milen ;

Abla, Oussama ;

van Wezel, Tom ;

van den Bos, Cor ;

van Halteren, Astrid G. S. .

BLOOD ADVANCES, 2023, 7 (04) :664-679

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