TRKing sarcomas for precision medicine: Seek, and ye shall find!

被引：1

作者：

Moyers, Justin T. ^{[1
]}

Subbiah, Vivek ^{[2
,3
]}

机构：

[1] Angeles Clin & Res Inst, Los Angeles, CA USA

[2] Sarah Cannon Res Inst, Early Phase Drug Dev, Nashville, TN USA

[3] Sarah Cannon Res Inst, 1100 Dr Martin L King Jr Blvd, Nashville, TN 37203 USA

来源：

CANCER | 2023年 / 129卷 / 23期

基金：

美国国家卫生研究院;

关键词：

GASTROINTESTINAL STROMAL TUMORS; EFFICACY; SAFETY;

D O I：

10.1002/cncr.34941

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The way in which we treat different types of cancer has changed a lot because of genome-driven precision oncology. This approach uses information from a person's genes to personalize their treatment.A recent study conducted by Kummar and colleagues confirms that neurotrophic receptor tyrosine kinase (NTRK) inhibitors are beneficial in treating sarcomas with NTRK fusions.This study adds to the growing evidence that genomics, which is the study of genes and their functions, can help us to identify effective treatments even for rare targets such as NTRK fusions.This emphasizes the importance of using advanced DNA sequencing techniques in analyzing the genetic makeup of all sarcomas.

引用

页码：3694 / 3696

页数：3

共 21 条

[1] Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033 [J].

Blanke, Charles D. ;

Rankin, Cathryn ;

Demetri, George D. ;

Ryan, Christopher W. ;

von Mehren, Margaret ;

Benjamin, Robert S. ;

Raymond, A. Kevin ;

Bramwell, Vivien H. C. ;

Baker, Laurence H. ;

Maki, Robert G. ;

Tanaka, Michael ;

Hecht, J. Randolph ;

Heinrich, Michael C. ;

Fletcher, Christopher D. M. ;

Crowley, John J. ;

Borden, Ernest C. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (04) :626-632

[2] Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor [J].

Butrynski, James E. ;

D'Adamo, David R. ;

Hornick, Jason L. ;

Dal Cin, Paola ;

Antonescu, Cristina R. ;

Jhanwar, Suresh C. ;

Ladanyi, Marc ;

Capelletti, Marzia ;

Rodig, Scott J. ;

Ramaiya, Nikhil ;

Kwak, Eunice L. ;

Clark, Jeffrey W. ;

Wilner, Keith D. ;

Christensen, James G. ;

Jaenne, Pasi A. ;

Maki, Robert G. ;

Demetri, George D. ;

Shapiro, Geoffrey I. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) :1727-1733

[3] Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101) [J].

Carmagnani Pestana, Roberto ;

Moyers, Justin T. ;

Roszik, Jason ;

Sen, Shiraj ;

Hong, David S. ;

Naing, Aung ;

Herzog, Cynthia E. ;

Fu, Siqing ;

Piha-Paul, Sarina A. ;

Rodon, Jordi ;

Yap, Timothy A. ;

Karp, Daniel D. ;

Tsimberidou, Apostolia M. ;

Pant, Shubham ;

Zarzour, Maria A. ;

Ratan, Ravin ;

Ravi, Vinod ;

Benjamin, Robert S. ;

Lazar, Alexander J. ;

Wang, Wei-Lien ;

Daw, Najat ;

Gill, Jonathan B. ;

Harrison, Douglas J. ;

Lewis, Valerae O. ;

Roland, Christina L. ;

Patel, Shreyaskumar R. ;

Livingston, J. Andrew ;

Somaiah, Neeta ;

Ludwig, Joseph A. ;

Conley, Anthony P. ;

Hamerschlak, Nelson ;

Gorlick, Richard ;

Meric-Bernstam, Funda ;

Subbiah, Vivek .

CLINICAL CANCER RESEARCH, 2023, 29 (09) :1708-1718

[4]

Chawla S., 2020, 2020 CTOS VIRT M

[5] Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1) [J].

Drilon, Alexander ;

Siena, Salvatore ;

Ou, Sai-Hong Ignatius ;

Patel, Manish ;

Ahn, Myung Ju ;

Lee, Jeeyun ;

Bauer, Todd M. ;

Farago, Anna F. ;

Wheler, Jennifer J. ;

Liu, Stephen V. ;

Doebele, Robert ;

Giannetta, Laura ;

Cerea, Giulio ;

Marrapese, Giovanna ;

Schirru, Michele ;

Amatu, Alessio ;

Bencardino, Katia ;

Palmeri, Laura ;

Sartore-Bianchi, Andrea ;

Vanzulli, Angelo ;

Cresta, Sara ;

Damian, Silvia ;

Duca, Matteo ;

Ardini, Elena ;

Li, Gang ;

Christiansen, Jason ;

Kowalski, Karey ;

Johnson, Ann D. ;

Patel, Rupal ;

Luo, David ;

Chow-Maneval, Edna ;

Hornby, Zachary ;

Multani, Pratik S. ;

Shaw, Alice T. ;

De Braud, Filippo G. .

CANCER DISCOVERY, 2017, 7 (04) :400-409

[6] Clinical trial design in the era of precision medicine [J].

Fountzilas, Elena ;

Tsimberidou, Apostolia M. ;

Vo, Henry Hiep ;

Kurzrock, Razelle .

GENOME MEDICINE, 2022, 14 (01)

[7] Phase II randomised trial comparing docetaxel given every 3 weeks with weekly schedule as second-line therapy in patients with advanced non-small-cell lung cancer (NSCLC) [J].

Gervais, R ;

Ducolone, A ;

Breton, JL ;

Braun, D ;

Lebeau, B ;

Vaylet, F ;

Debieuvre, D ;

Pujol, JL ;

Tredaniel, J ;

Clouet, P ;

Quoix, E .

ANNALS OF ONCOLOGY, 2005, 16 (01) :90-96

[8] Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications [J].

Gouda, Mohamed A. ;

Nelson, Blessie E. ;

Buschhorn, Lars ;

Wahida, Adam ;

Subbiah, Vivek .

CLINICAL CANCER RESEARCH, 2023, 29 (15) :2753-2760

[9] Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma [J].

Gounder, Mrinal M. ;

Agaram, Narasimhan P. ;

Trabucco, Sally E. ;

Robinson, Victoria ;

Ferraro, Richard A. ;

Millis, Sherri Z. ;

Krishnan, Anita ;

Lee, Jessica ;

Attia, Steven ;

Abida, Wassim ;

Drilon, Alexander ;

Chi, Ping ;

D'Angelo, Sandra P. ;

Dickson, Mark A. ;

Keohan, Mary Lou ;

Kelly, Ciara M. ;

Agulnik, Mark ;

Chawla, Sant P. ;

Choy, Edwin ;

Chugh, Rashmi ;

Meyer, Christian F. ;

Myer, Parvathi A. ;

Moore, Jessica L. ;

Okimoto, Ross A. ;

Pollock, Raphael E. ;

Ravi, Vinod ;

Singh, Arun S. ;

Somaiah, Neeta ;

Wagner, Andrew J. ;

Healey, John H. ;

Frampton, Garrett M. ;

Venstrom, Jeffrey M. ;

Ross, Jeffrey S. ;

Ladanyi, Marc ;

Singer, Samuel ;

Brennan, Murray F. ;

Schwartz, Gary K. ;

Lazar, Alexander J. ;

Thomas, David M. ;

Maki, Robert G. ;

Tap, William D. ;

Ali, Siraj M. ;

Jin, Dexter X. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[10]

Kummar S., 2023, CANCER, V129

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