Oncogenic viruses and host lipid metabolism: a new perspective

被引：3

作者：

Gong, Zhiyuan ^{[1
]}

Yan, Zhiyong ^{[1
]}

Liu, Wen ^{[1
]}

Luo, Bing ^{[1
]}

机构：

[1] Qingdao Univ, Sch Basic Med, Dept Pathogen Biol, Qingdao 266071, Peoples R China

来源：

JOURNAL OF GENERAL VIROLOGY | 2023年 / 104卷 / 06期

关键词：

oncogenic viruses; lipid metabolism; antiviral agents; viral diseases; EPSTEIN-BARR-VIRUS; HEPATITIS-B-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; FATTY-ACID SYNTHASE; T-CELL LEUKEMIA; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; ACTIVATED PROTEIN-KINASE; X PROTEIN; C-MYC; GENE-EXPRESSION;

D O I：

10.1099/jgv.0.001861

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

As noncellular organisms, viruses do not have their own metabolism and rely on the metabolism of host cells to provide energy and metabolic substances for their life cycles. Increasing evidence suggests that host cells infected with oncogenic viruses have dramatically altered metabolic requirements and that oncogenic viruses produce substances used for viral replication and virion production by altering host cell metabolism. We focused on the processes by which oncogenic viruses manipulate host lipid metabolism and the lipid metabolism disorders that occur in oncogenic virus-associated diseases. A deeper understanding of viral infections that cause changes in host lipid metabolism could help with the development of new antiviral agents as well as potential new therapeutic targets.

引用

页数：17

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