Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children

被引：6

作者：

Fialho, Eder M. S. ^{[1
]}

Veras, Emanoel M. ^{[2
]}

de Jesus, Caroline M. ^{[3
]}

Gomes, Lillian N. ^{[4
]}

Khouri, Ricardo ^{[5
]}

Sousa, Patricia S. ^{[6
]}

Ribeiro, Marizelia R. C. ^{[7
]}

Batista, Rosangela F. L. ^{[8
]}

Costa, Luciana C. ^{[8
]}

Nascimento, Flavia R. F. ^{[1
,9
]}

Silva, Antonio A. M. ^{[8
]}

Soeiro-Pereira, Paulo V. ^{[1
,9
]}

机构：

[1] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Hlth Sci Grad Program, BR-65080805 Sao Luis, MA, Brazil

[2] Univ Fed Maranhao, Med Sch, BR-65080805 Sao Luis, MA, Brazil

[3] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Hlth & Technol Grad Program, BR-65080805 Sao Luis, MA, Brazil

[4] Univ Sao Paulo, Dept Immunol, BR-05508000 Sao Paulo, SP, Brazil

[5] FIOCRUZ Bahia, Goncalo Moniz Res Inst, BR-40296710 Salvador, BA, Brazil

[6] Reference Ctr Neurodev Assistance & Rehabil Childr, State Dept Hlth State Maranhao, BR-65077357 Sao Luis, MA, Brazil

[7] Univ Fed Maranhao, Dept Med 3, BR-65020240 Sao Luis, MA, Brazil

[8] Univ Fed Maranhao, Dept Publ Hlth, BR-65020060 Sao Luis, MA, Brazil

[9] Univ Fed Maranhao, Dept Pathol, BR-65065545 Sao Luis, MA, Brazil

来源：

VIRUSES-BASEL | 2023年 / 15卷 / 06期

关键词：

vertical transmission; microcephaly; disease infection; interleukin-17; IMMUNE ACTIVATION; TRANSMISSION; EXPOSURE; DEFECTS; INFANTS; BRAZIL; BIRTH;

D O I：

10.3390/v15061320

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers' and children's immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers' immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.

引用

页数：16

共 50 条

[11] Association between Zika virus and microcephaly in French Polynesia, 2013-15: a retrospective study [J].

Cauchemez, Simon ;

Besnard, Marianne ;

Bompard, Priscillia ;

Dub, Timothee ;

Guillemette-Artur, Prisca ;

Eyrolle-Guignot, Dominique ;

Salje, Henrik ;

Van Kerkhove, Maria D. ;

Abadie, VRonique ;

Garel, Catherine ;

Fontanet, Arnaud ;

Mallet, Henri-Pierre .

LANCET, 2016, 387 (10033) :2125-2132

[12] The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring [J].

Choi, Gloria B. ;

Yim, Yeong S. ;

Wong, Helen ;

Kim, Sangdoo ;

Kim, Hyunju ;

Kim, Sangwon V. ;

Hoeffer, Charles A. ;

Littman, Dan R. ;

Huh, Jun R. .

SCIENCE, 2016, 351 (6276) :933-939

[13] Innate Immune Responses to Acute Viral Infection During Pregnancy [J].

Cornish, Emily F. ;

Filipovic, Iva ;

asenius, Fredrika ;

Williams, David J. ;

McDonnell, Thomas .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[14] The Brazilian Zika virus strain causes birth defects in experimental models [J].

Cugola, Fernanda R. ;

Fernandes, Isabella R. ;

Russo, Fabiele B. ;

Freitas, Beatriz C. ;

Dias, Joao L. M. ;

Guimaraes, Katia P. ;

Benazzato, Cecilia ;

Almeida, Nathalia ;

Pignatari, Graciela C. ;

Romero, Sarah ;

Polonio, Carolina M. ;

Cunha, Isabela ;

Freitas, Carla L. ;

Brandao, Wesley N. ;

Rossato, Cristiano ;

Andrade, David G. ;

Faria, Daniele de P. ;

Garcez, Alexandre T. ;

Buchpigel, Carlos A. ;

Braconi, Carla T. ;

Mendes, Erica ;

Sall, Amadou A. ;

Zanotto, Paolo M. de A. ;

Peron, Jean Pierre S. ;

Muotri, Alysson R. ;

Beltrao-Braga, Patricia C. B. .

NATURE, 2016, 534 (7606) :267-+

[15] Zika virus damages the human placental barrier and presents marked fetal neurotropism [J].

de Noronha, Lucia ;

Zanluca, Camila ;

Viola Azevedo, Marina Luize ;

Luz, Kleber Giovanni ;

Duarte dos Santos, Claudia Nunes .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2016, 111 (05) :287-+

[16] Congenital Zika Virus Infection Beyond Neonatal Microcephaly [J].

de Oliveira Melo, Adriana Suely ;

Aguiar, Renato Santana ;

Ramos Amorim, Melania Maria ;

Arruda, Monica B. ;

Melo, Fabiana de Oliveira ;

Clementino Ribeiro, Suelem Tais ;

Medeiros Batista, Alba Gean ;

Ferreira, Thales ;

dos Santos, Mayra Pereira ;

Sampaio, Virginia Vilar ;

Martins Moura, Sarah Rogeria ;

Rabello, Luciana Portela ;

Gonzaga, Clarissa Emanuelle ;

Malinger, Gustavo ;

Ximenes, Renato ;

de Oliveira-Szejnfeld, Patricia Soares ;

Tovar-Moll, Fernanda ;

Chimelli, Leila ;

Silveira, Paola Paz ;

Delvechio, Rodrigo ;

Higa, Luiza ;

Campanati, Loraine ;

Nogueira, Rita M. R. ;

Bispo Filippis, Ana Maria ;

Szejnfeld, Jacob ;

Voloch, Carolina Moreira ;

Ferreira, Orlando C., Jr. ;

Brindeiro, Rodrigo M. ;

Tanuri, Amilcar .

JAMA NEUROLOGY, 2016, 73 (12) :1407-1416

[17] Zika virus in the Americas: Early epidemiological and genetic findings [J].

Faria, Nuno Rodrigues ;

da Silva Azevedo, Raimunda do Socorro ;

Kraemer, Moritz U. G. ;

Souza, Renato ;

Cunha, Mariana Sequetin ;

Hill, Sarah C. ;

Theze, Julien ;

Bonsall, Michael B. ;

Bowden, Thomas A. ;

Rissanen, Ilona ;

Rocco, Iray Maria ;

Nogueira, Juliana Silva ;

Maeda, Adriana Yurika ;

da Silva Vasami, Fernanda Giseli ;

de Lima Macedo, Fernando Luiz ;

Suzuki, Akemi ;

Rodrigues, Sueli Guerreiro ;

Ribeiro Cruz, Ana Cecilia ;

Nunes, Bruno Tardeli ;

de Almeida Medeiros, Daniele Barbosa ;

Guerreiro Rodrigues, Daniela Sueli ;

Nunes Queiroz, Alice Louize ;

Pinto da Silva, Eliana Vieira ;

Henriques, Daniele Freitas ;

Travassos da Rosa, Elisabeth Salbe ;

de Oliveira, Consuelo Silva ;

Martins, Livia Caricio ;

Vasconcelos, Helena Baldez ;

Neves Casseb, Livia Medeiros ;

Simith, Darlene de Brito ;

Messina, Jane P. ;

Abade, Leandro ;

Loureno, Jose ;

Junior Alcantara, Luiz Carlos ;

de Lima, Maricelia Maia ;

Giovanetti, Marta ;

Hay, Simon I. ;

de Oliveira, Rodrigo Santos ;

Lemos, Poliana da Silva ;

de Oliveira, Layanna Freitas ;

Silva de Lima, Clayton Pereira ;

da Silva, Sandro Patroca ;

de Vasconcelos, Janaina Mota ;

Franco, Luciano ;

Cardoso, Jedson Ferreira ;

da Silva Gonalves Vianez-Junior, Joao Lidio ;

Mir, Daiana ;

Bello, Gonzalo ;

Delatorre, Edson ;

Khan, Kamran .

SCIENCE, 2016, 352 (6283) :345-349

[18] Maternal Immune Response to ZIKV Triggers High-Inflammatory Profile in Congenital Zika Syndrome [J].

Fialho, Eder M. S. ;

Veras, Emanoel M. ;

de Jesus, Caroline M. ;

Khouri, Ricardo ;

Sousa, Patricia S. ;

Ribeiro, Marizelia R. C. ;

Costa, Luciana C. ;

Gomes, Lillian N. ;

Nascimento, Flavia R. F. ;

Silva, Antonio A. M. ;

Soeiro-Pereira, Paulo V. .

VIRUSES-BASEL, 2023, 15 (01)

[19] Asian Zika virus strains target CD14+ blood monocytes and induce M2-skewed immunosuppression during pregnancy [J].

Foo, Suan-Sin ;

Chen, Weiqiang ;

Chan, Yen ;

Bowman, James W. ;

Chang, Lin-Chun ;

Choi, Younho ;

Yoo, Ji Seung ;

Ge, Jianning ;

Cheng, Genhong ;

Bonnin, Alexandre ;

Nielsen-Saines, Karin ;

Brasil, Patricia ;

Jung, Jae U. .

NATURE MICROBIOLOGY, 2017, 2 (11) :1558-1570

[20] Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation [J].

Franca, Giovanny V. A. ;

Schuler-Faccini, Lavinia ;

Oliveira, Wanderson K. ;

Henriques, Claudio M. P. ;

Carmo, Eduardo H. ;

Pedi, Vaneide D. ;

Nunes, Marilia L. ;

Castro, Marcia C. ;

Serruya, Suzanne ;

Silveira, Mariangela F. ;

Barros, Fernando C. ;

Victora, Cesar G. .

LANCET, 2016, 388 (10047) :891-897

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